| Gene Symbol | CD74 |
|---|---|
| Entrez Gene | 972 |
| Alt Symbol | DHLAG, HLADG, II, Ia-GAMMA |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD74 molecule, major histocompatibility complex, class II invariant chain |
| Other Description | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)|HLA class II histocompatibility antigen gamma chain|HLA-DR antigens-associated invariant chain|HLA-DR-gamma|Ia-associated invariant chain|MHC HLA-DR gamma chain|gamma chain of class II antigens|p33 |
| Swissprots | D3DQG3 A8K7R1 Q8SNA0 B4DNE8 Q8WLP6 Q5U0J8 D3DQG4 Q14597 Q29832 P04233 |
| Accessions | AAA36033 CAA27046 CAA27047 EAW61727 EAW61728 EAW61729 EAW61730 EAW61731 P04233 AK292076 BAF84765 AK297889 BAG60210 AK300669 BAG62354 AK308929 BC018726 AAH18726 BC024272 AAH24272 BF796148 BT019505 AAV38312 DC354760 DQ892005 ABM82931 DQ895194 ABM86120 K01144 AAA36304 M28588 AAA58655 M28589 AAO49820 M28590 AAA35996 X00497 CAA25192 NM_001025158 NP_001020329 NM_001025159 NP_001020330 NM_004355 NP_004346 |
| Function | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. |
| Subcellular Location | Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane. |
| Top Pathways | Tuberculosis, Herpes simplex infection, Antigen processing and presentation |
CD74 siRNA (h) - sc-35023 from Santa Cruz Biotechnology
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CD74 shRNA Plasmid (h) - sc-35023-SH from Santa Cruz Biotechnology
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CD74 shRNA (h) Lentiviral Particles - sc-35023-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU157961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5749 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5749 from Sigma-Aldrich
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CD74 siRNA (Human) - CRH0693 from Cohesion Biosciences
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CD74 CRISPR/Cas9 KO Plasmid (h) - sc-400279 from Santa Cruz Biotechnology
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CD74 HDR Plasmid (h) - sc-400279-HDR from Santa Cruz Biotechnology
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CD74 Double Nickase Plasmid (h) - sc-400279-NIC from Santa Cruz Biotechnology
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CD74 Double Nickase Plasmid (h2) - sc-400279-NIC-2 from Santa Cruz Biotechnology
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CD74 CRISPR Activation Plasmid (h) - sc-400279-ACT from Santa Cruz Biotechnology
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CD74 CRISPR Activation Plasmid (h2) - sc-400279-ACT-2 from Santa Cruz Biotechnology
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CD74 Lentiviral Activation Particles (h) - sc-400279-LAC from Santa Cruz Biotechnology
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CD74 Lentiviral Activation Particles (h2) - sc-400279-LAC-2 from Santa Cruz Biotechnology
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CD74 - MBS8232594 from MyBioSource
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CD74 siRNA (h2) - sc-42802 from Santa Cruz Biotechnology
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CD74 shRNA Plasmid (h2) - sc-42802-SH from Santa Cruz Biotechnology
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CD74 shRNA (h2) Lentiviral Particles - sc-42802-V from Santa Cruz Biotechnology
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shRNA set against Human CD74 (NM_004355.3) - SHH259341 from Creative biogene
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Human CD74 siRNA - orb261195 from Biorbyt
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CD74 shRNA Plasmid (Human) - CHH0693 from Cohesion Biosciences
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CD74 miRNA 3'UTR clone - MiUTR3H-01078 from Creative biogene
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CD74 miRNA 3'UTR clone - MiUTR3H-01079 from Creative biogene
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CD74 miRNA 3'UTR clone - MiUTR3H-01080 from Creative biogene
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