Ggt1

Gene Symbol Ggt1
Entrez Gene 116568
Alt Symbol GGLUT, Ggt, Ggtp
Species Rat
Gene Type protein-coding
Description gamma-glutamyltransferase 1
Other Description GGT 1|gamma glutamyl-transferase 1|gamma-glutamyl transpeptidase|gamma-glutamyltranspeptidase 1|glutathione hydrolase 1|leukotriene-C4 hydrolase
Swissprots Q63218 Q6AZ32 Q63217 P07314
Accessions AAA41217 EDL97199 EDL97200 EDL97201 EDL97202 EDL97203 EDL97204 EDL97205 EDL97206 EDL97207 EDL97208 EDL97209 EDL97210 EDL97211 EDL97212 P07314 BC078768 AAH78768 M33821 AAA57295 M33822 AAB59698 X15443 CAA33483 NM_053840 NP_446292
Function Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Detected in adult kidney and mammary gland, and in fetal liver.
Top Pathways Taurine and hypotaurine metabolism, Glutathione metabolism, Arachidonic acid metabolism, Cyanoamino acid metabolism

Rat Ggt1 cDAN Clone(NM_053840.2) - CDFR013574 from Creative Biomart

Species Rat
Accession NM_053840.2

Rat GGT1 ORF clone(NM_053840.2) - CDCL184404 from Creative Biomart

Species Rat
Accession NM_053840.2

Rat Ggt1 ORF Clone(NM_053840.2) - CDCR380606 from Creative Biomart

Species Rat
Accession NM_053840.2

Rat GGT1 ORF clone(NM_053840.2) - CDCL184404 from Creative biogene

Species Rat

Rat Ggt1 cDNA Clone(NM_053840.2) - CDFR013574 from Creative biogene

Species Rat
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