| Gene Symbol |
Acox1
|
| Entrez Gene |
11430
|
| Alt Symbol |
AOX, Acox, D130055E20Rik, Paox
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
acyl-Coenzyme A oxidase 1, palmitoyl
|
| Other Description |
palmitoyl-CoA oxidase|peroxisomal acyl-coenzyme A oxidase 1|peroxisomal fatty acyl-coenzyme A oxidase|peroxisomal straight-chain Acyl-CoA oxidase
|
| Swissprots |
Q9R0H0 O35616 Q3TDG0 Q8BYC3 A2A850
|
| Accessions |
CBF60568 CBF65722 CBF73098 CBU85812 CBU90593 CBU96009 EDL34562 EDL34563 Q9R0H0 AB034914 BAA86870 AF006688 AAB62926 AK034760 AK040566 BAC30628 AK051539 AK054446 BAC35782 AK128941 AK170217 BAE41642 AK206375 AK210300 AK215118 BC054727 BC056448 AAH56448 XM_006532002 XP_006532065 NM_001271898 NP_001258827 NM_015729 NP_056544
|
| Function |
Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Peroxisome {ECO:0000250}.
|
| Tissue Specificity |
Highest levels of isoform 1 are found in liver and kidney while highest levels of isoform 2 are found in white adipose tissue. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 is expressed at higher levels in brain, heart, lung, muscle, white adipose tissue and testis. {ECO:0000269|PubMed:20195242}.
|
| Top Pathways |
PPAR signaling pathway, Peroxisome, cAMP signaling pathway, alpha-Linolenic acid metabolism, Fatty acid degradation
|
