Acox1

Gene Symbol Acox1
Entrez Gene 11430
Alt Symbol AOX, Acox, D130055E20Rik, Paox
Species Mouse
Gene Type protein-coding
Description acyl-Coenzyme A oxidase 1, palmitoyl
Other Description palmitoyl-CoA oxidase|peroxisomal acyl-coenzyme A oxidase 1|peroxisomal fatty acyl-coenzyme A oxidase|peroxisomal straight-chain Acyl-CoA oxidase
Swissprots Q9R0H0 O35616 Q3TDG0 Q8BYC3 A2A850
Accessions CBF60568 CBF65722 CBF73098 CBU85812 CBU90593 CBU96009 EDL34562 EDL34563 Q9R0H0 AB034914 BAA86870 AF006688 AAB62926 AK034760 AK040566 BAC30628 AK051539 AK054446 BAC35782 AK128941 AK170217 BAE41642 AK206375 AK210300 AK215118 BC054727 BC056448 AAH56448 XM_006532002 XP_006532065 NM_001271898 NP_001258827 NM_015729 NP_056544
Function Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). {ECO:0000250}.
Subcellular Location Peroxisome {ECO:0000250}.
Tissue Specificity Highest levels of isoform 1 are found in liver and kidney while highest levels of isoform 2 are found in white adipose tissue. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 is expressed at higher levels in brain, heart, lung, muscle, white adipose tissue and testis. {ECO:0000269|PubMed:20195242}.
Top Pathways PPAR signaling pathway, Peroxisome, cAMP signaling pathway, alpha-Linolenic acid metabolism, Fatty acid degradation