Notch1

Gene Symbol	Notch1
Entrez Gene	18128
Alt Symbol	9930111A19Rik, Mis6, N1, Tan1, lin-12
Species	Mouse
Gene Type	protein-coding
Description	notch 1
Other Description	Motch A|Notch gene homolog 1|mT14|major type A protein|neurogenic locus notch homolog protein 1|p300|transmembrane receptor Notch1
Swissprots	Q9QW58 Q99JC2 Q8K428 Q7TQ52 Q9R0X7 Q3TZW2 Q06007 Q01705 Q3U3Y2 Q7TQ50 Q61905 Q7TQ51
Accessions	BAC77038 BAC77039 BAC77040 CAL48809 EDL08321 Q01705 AB101624 AB101625 AB101626 AB101627 AB101628 AB101629 AB101630 AB101631 AB101632 AB101633 AB101634 AB101636 AB101637 AF508809 AAM28905 AJ238029 CAB40733 AK004408 AK042197 BAC31194 AK054089 AK079454 AK090118 AK149054 AK154528 BAE32653 AK157475 BAE34095 AK157979 AK171329 BC010325 BC058427 BC138441 AAI38442 BC138442 AAI38443 BF318436 BY233933 L02613 AAK14898 X68278 CAA48339 X82562 CAA57909 Z11886 CAA77941 Z21925 NM_008714 NP_032740
Function	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Highly expressed in the brain, lung and thymus. Expressed at lower levels in the spleen, bone-marrow, spinal cord, eyes, mammary gland, liver, intestine, skeletal muscle, kidney and heart. In the hair follicle, highly expressed exclusively in the epithelial compartment. {ECO:0000269|PubMed:15965470}.
Top Pathways	Notch signaling pathway, Prion diseases, MicroRNAs in cancer, Dorso-ventral axis formation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Notch 1 (8G10) - sc-32756 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Hamster Clonality Monoclonal

Notch 1 (M-20) - sc-6015 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Notch 1 (4i50) - sc-71719 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Hamster Clonality Monoclonal

cleaved Notch 1 (m1711) - sc-23307 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Notch1 antibody - ab33932 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Notch1 antibody [4i50] - ab64570 from Abcam Prices $372.00 Sizes 100 µl Clonality Monoclonal Clone 4i50

Anti-Notch1 antibody [S253-32] - ab167441 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S253-32

Notch-1 Antibody (mN1A) - NB100-78486 from Novus Biologicals Prices $99.00, $299.00 Sizes 25 µl, 100 µl Host Mouse Clonality Monoclonal Clone mN1A

Notch-1 Antibody - AF5267 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Sheep Clonality Polyclonal

Notch-1 Antibody (N1A) [Unconjugated] - MAB5267 from Novus Biologicals Prices $99.00, $249.00 Sizes 25 µg, 100 µg Host Mouse Clonality Monoclonal Clone N1A

Notch-1 Antibody (S253-32) - NBP2-22406 from Novus Biologicals Prices $329.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S253-32

Notch-1 Antibody [Biotin] - BAF5267 from Novus Biologicals Prices $390.00 Sizes 50 µg Host Sheep Clonality Polyclonal

Notch-1 Antibody (N1A) [PE] - IC5267P from Novus Biologicals Host Mouse Clonality Monoclonal Clone N1A

Notch-1 Antibody (N1A) [PerCP] - IC5267C from Novus Biologicals Host Mouse Clonality Monoclonal Clone N1A

Monoclonal Anti-Notch1 - Fitc antibody produced in mouse - SAB5200918 from Sigma-Aldrich Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S253-32

Monoclonal Anti-Notch1 - Streptavidin antibody produced in mouse - SAB5200923 from Sigma-Aldrich Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S253-32

Monoclonal Anti-Notch1 - Atto 700 antibody produced in mouse - SAB5200914 from Sigma-Aldrich Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S253-32

Monoclonal Anti-Notch1 - Hrp antibody produced in mouse - SAB5200919 from Sigma-Aldrich Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S253-32

Monoclonal Anti-Notch1 - Percp antibody produced in mouse - SAB5200921 from Sigma-Aldrich Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S253-32

Monoclonal Anti-Notch1 - Atto 594 antibody produced in mouse - SAB5200910 from Sigma-Aldrich Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S253-32

Monoclonal Anti-Notch1 - Atto 488 antibody produced in mouse - SAB5200908 from Sigma-Aldrich Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S253-32

Monoclonal Anti-Notch1 - Atto 390 antibody produced in mouse - SAB5200907 from Sigma-Aldrich Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S253-32

Monoclonal Anti-Notch1 - Alkaline Phosphatase antibody produced in mouse - SAB5200915 from Sigma-Aldrich Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S253-32

Monoclonal Anti-Notch1 - Atto 655 antibody produced in mouse - SAB5200912 from Sigma-Aldrich Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S253-32

Monoclonal Anti-Notch1 - Biotin antibody produced in mouse - SAB5200917 from Sigma-Aldrich Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S253-32

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