| Gene Symbol |
Ikbke
|
| Entrez Gene |
56489
|
| Alt Symbol |
AW558201, IKK-i, IKKepsilon, Ikki
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
inhibitor of kappaB kinase epsilon
|
| Other Description |
I-kappa-B kinase epsilon|IKK-E|IKK-epsilon|inducible I kappa-B kinase|inducible IKappaB kinase|inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon|inhibitor of nuclear factor kappa-B kinase subunit epsilon
|
| Swissprots |
Q9R0T8 Q8C2I3
|
| Accessions |
EDL39710 EDL39711 EDL39712 Q9R0T8 AB016589 BAA85154 AK088580 BAC40434 AK149911 BAE29161 AK153046 BAE31675 AK180824 AK193494 AK198423 AK209824 AK213678 AK218764 AK220324 BAD90396 BC037446 AAH37446 CT010206 CAJ18414 CT010313 CAJ18521 XM_006529762 XP_006529825 XM_006529763 XP_006529826 XM_006529764 XP_006529827 XM_011248052 XP_011246354 XR_387186 NM_019777 NP_062751
|
| Function |
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG- I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1,
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in bone marrow-derived macrophages and at low levels in liver and white adipose tissue (at protein level). Detected in muscle and lung. {ECO:0000269|PubMed:17332413, ECO:0000269|PubMed:19737522, ECO:0000269|PubMed:23396211}.
|
| Top Pathways |
Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Hepatitis C, Measles
|