ICA1

Gene Symbol	ICA1
Entrez Gene	3382
Alt Symbol	ICA69, ICAp69
Species	Human
Gene Type	protein-coding
Description	islet cell autoantigen 1, 69kDa
Other Description	69 kDa islet cell autoantigen|diabetes mellitus type I autoantigen|islet cell autoantigen 1|islet cell autoantigen 1 isoform|islet cell autoantigen p69|p69
Swissprots	Q96HG3 Q13824 P78506 Q05084 B3FTQ2 A8K7U1
Accessions	AAB19035 AAB94737 AAB94738 AAD50515 AAF20020 AAF20021 CAY55971 CAY55972 EAW93610 EAW93611 EAW93612 EAW93613 EAW93614 EAW93615 EAW93616 EAW93617 EAW93618 EAW93619 EAW93620 Q05084 AA581444 AI346099 AK292106 BAF84795 AM393016 CAL37894 BC005922 BC008640 AAH08640 BM716117 BU728575 DA076379 DA154134 DB010744 DB040266 DQ891505 ABM82431 EU176613 ABW03414 EU416199 ACB47390 L01100 AAA02564 L21181 AAA64927 U26591 AAB19033 U26592 AAB19034 U37183 AAC50935 U38260 AAC50936 XM_005249735 XP_005249792 XM_011515345 XP_011513647 XM_011515346 XP_011513648 XM_011515347 XP_011513649 XM_011515348 XP_011513650 XM_011515349 XP_011513651 XM_011515350 XP_011513652 XM_011515351 XP_011513653 XM_011515352 XP_011513654 XM_011515353 XP_011513655 XM_011515354 XP_011513656 XM_011515355 XP_011513657 XM_011515356 XP_011513658 XM_011515357 XP_011513659 XR_926934 XR_926935 NM_001136020 NP_001129492 NM_001276478 NP_001263407 NM_004968 NP_004959 NM_022307 NP_071682 NM_022308
Function	May play a role in neurotransmitter secretion. {ECO:0000250}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:12682071}. Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.
Tissue Specificity	Expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid.
Top Pathways	Type I diabetes mellitus

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ICA1 protein fragment - ab116929 from Abcam Category Protein Source Wheat germ Species Human

ICA69 / ICA1 Antibody Blocking Peptide - LS-E4484 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ICA69 / ICA1 Antibody Blocking Peptide - LS-E19731 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ICA69 / ICA1 Antibody Blocking Peptide - LS-E19732 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ICA1 Protein - H00003382-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ICA1-Antibody-N-term-Blocking-Peptide - BP16802a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant human Islet cell autoantigen 1 (OPCA00123) - OPCA00123 from Aviva Systems Biology Category Protein Prices $198.00 Sizes 50 µg Species Human

Recombinant human Islet cell autoantigen 1 (OPCA01249) - OPCA01249 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human ICA1 protein - orb244282 from Biorbyt Category Protein Prices $315.00, $502.00, $782.00, $1,139.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human ICA1 protein - orb245869 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

ICA1 Blocking Peptide - 33R-8545 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ICA1 Blocking Peptide - 33R-6795 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ICA1 protein - 30-1384 from Fitzgerald Category Protein Prices $335.00 Sizes 500 µg Source E.coli

Human ICA1 Protein - abx067565 from Abbexa Category Protein Source E.coli Species Human

Islet cell autoantigen 1 / ICA1 - H00003382-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Islet cell autoantigen 1 / ICA1 - H00003382-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Islet Cell Autoantigen 1 (ICA1), Human - 20-8522 from ARP American Research Products Category Protein Prices $549.00 Sizes 50 µg Source E.coli Species Human

ICA1 fusion protein - ag1219 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

ICA1 fusion protein - ag4372 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human ICA1 protein, GST-tagged - ICA1-28632TH from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Islet Cell Autoantigen 1 (ICA1) - RPC538Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Islet Cell Autoantigen 1 (ICA1) - RPC538Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Islet Cell Autoantigen 1 (ICA1) - RPC538Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant human Islet cell autoantigen 1 - CSB-YP010947HU CSB-BP010947HU CSB-MP010947HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant Human Islet cell autoantigen 1(ICA1) - CSB-EP010947HU from Cusabio Category Protein Source Yeast Species Human

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