INSM1

Gene Symbol INSM1
Entrez Gene 3642
Alt Symbol IA-1, IA1
Species Human
Gene Type protein-coding
Description insulinoma-associated 1
Other Description insulinoma-associated protein 1|zinc finger protein IA-1
Swissprots Q01101
Accessions AAA20938 Q01101 BM503821 M93119 AAA58680 NM_002196 NP_002187
Function Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle- specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and
Subcellular Location Nucleus {ECO:0000250}.
Tissue Specificity Expressed in pancreatic duct cells. Expressed in several tumor cell lines of neuroendocrine origin including pheochromocytoma, medullary thyroid carcinoma, insulinoma, medulloblastoma, retinoblastoma, pheochromacytoma, medullary thyroid carcinoma and small cell lung carcinoma. {ECO:0000269|PubMed:12890672, ECO:0000269|PubMed:1634555}.

INSM1 (A-8) - sc-271408 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
INSM1 (A-8): sc-271408. Western blot analysis of INSM1 expression in TT whole cell lysate.

INSM1 (C-1) - sc-377428 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
INSM1 (C-1): sc-377428. Western blot analysis of INSM1 expression in AtT-20/D16vF2 (A), PC-12 (B), GH3 (C) and RIN-m5F (D) whole cell lysates.

INSM1 (H-45) - sc-68355 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
INSM1 (H-45): sc-68355. Western blot analysis of INSM1 expression in non-transfected 293T: sc-117752 (A), mouse INSM1 transfected 293T: sc-127011 (B) and TT (C) whole cell lysates.

INSM1 (P-15) - sc-54223 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

INSM1 (S-19) - sc-54224 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
INSM1 (S-19): sc-54224. Western blot analysis of INSM1 expression in TT whole cell lysate.

INSM1 (Y-17) - sc-54225 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
INSM1 (Y-17): sc-54225. Western blot analysis of INSM1 expression in TT whole cell lysate.

Anti-INSM1 antibody - ab30940 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-INSM1 antibody (ab30940) at 0.5 µg/ml (in 5% skim milk / PBS buffer) + fetal lung lysate at 10 µg/mlSecondaryHRP conjugated anti Rabbit IgG at 1/50000 dilution

Anti-INSM1 antibody - ab91564 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-INSM1 antibody (ab91564) at 1 µg/ml + Rat thymus tissue lysate at 15 µg

Anti-INSM1 antibody [EPR12044(B)] - ab170876 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12044(B)
Western blot analysis on immunoprecipitation pellet from fetal brain lysate labeling INSM1 using ab170876 at a 1/10 dilution and HRP-conjugated anti-rabbit IgG preferentially detecting the non-reduced form of rabbit IgG.

Anti-INSM1 Antibody (C-Terminus) - LS-C29921 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal Lung Lysate

Anti-INSM1 Antibody (aa191-240) - LS-C31212 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Fetal Cerebellum Lysate

Anti-INSM1 Antibody (N-Terminus) - LS-C108598 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot of IA-1 in rat thymus tissue lysate with IA-1 antibody at 1 ug/ml.

HDAC1 Antibody - NB100-56340 from Novus Biologicals

Prices $99.00, $329.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: HDAC1 Antibody [NB100-56340] - analysis of HDAC1 in 293 cell lysate with this antibody.

INSM1 Antibody - NBP1-76307 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-INSM1 antibody produced in rabbit - AV32667 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: fetal lung (<B>Cat. No. AV32667</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 0.5 μg/mL in cell type fetal lung

Anti-INSM1 antibody produced in rabbit - AV31990 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-INSM1: <B>Cat. No. AV31990</B>: Immunohistochemistry of INSM1 in Human Heart tissue with INSM1 antibody at 4-8 μg/mL.

Anti-IA-1 antibody produced in rabbit - SAB3500277 from Sigma-Aldrich

Prices $348.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-IA-1: <B>Cat. No. SAB3500277</B>: Western blot analysis of IA-1 in rat thymus tissue lysate with IA-1 antibody at 1 μg/mL.

INSM1 antibody - middle region (ARP31990_T100) - ARP31990_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

INSM1 antibody - C-terminal region (ARP32667_P050) - ARP32667_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

IA-1 antibody - GTX85243 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Anti-IA-1 antibody used in Western blot. GTX85243

IA 1 antibody - orb75283 from Biorbyt

Prices $723.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of rat thymus tissue lysate at 1 ug/mL using IA 1 antibody

Anti -INSM1 (Insulinoma-associated Protein 1, Zinc Finger Protein IA-1, IA1, IA-1) - 146523 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

INSM1 / IA1 antibody - AP30396PU-N from Acris Antibodies

Prices $340.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of IA-1 in rat thymus tissue lysate with AP30396PU-N IA-1 antibody at 1 μg/ml.

IA-1 Antibody - 5415 from ProSci

Prices $79.00, $325.00
Sizes 20 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of IA-1 in rat thymus tissue lysate with IA-1 antibody at 1 μg/mL.

INSM1 Antibody - 27-468 from ProSci

Prices $250.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Antibody used in IHC on Human Heart lysate.
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