| Gene Symbol |
Kcnj2
|
| Entrez Gene |
16518
|
| Alt Symbol |
IRK1, Kcnf1, Kir2.1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
potassium inwardly-rectifying channel, subfamily J, member 2
|
| Other Description |
IRK-1|inward rectifier K(+) channel Kir2.1|inward rectifier potassium channel 2|potassium channel, inwardly rectifying subfamily J member 2
|
| Swissprots |
P35561
|
| Accessions |
EDL34393 P35561 AF021136 AAB88794 AK044915 BAC32139 AK163198 BB642909 BC137841 AAI37842 BC137842 AAI37843 BP762467 X73052 CAA51526 NM_008425 NP_032451
|
| Function |
Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein. Membrane; Lipid-anchor {ECO:0000250|UniProtKB:P63252}.
|
| Tissue Specificity |
Prominently expressed in the central nervous system. Also found in other excitable tissues such as heart and skeletal muscle.
|
| Top Pathways |
Gastric acid secretion, Oxytocin signaling pathway
|