| Gene Symbol |
SEC22B
|
| Entrez Gene |
9554
|
| Alt Symbol |
ERS-24, SEC22L1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
|
| Other Description |
ER-Golgi SNARE of 24 kDa|SEC22 vesicle trafficking protein-like 1|SEC22 vesicle-trafficking protein homolog B|vesicle-trafficking protein SEC22b
|
| Swissprots |
A8K1G0 O75396
|
| Accessions |
O75396 AA135767 AF047442 AAC39893 AI085383 AK289875 BAF82564 BC001364 AAH01364 BU741516 CD619408 DQ892584 ABM83510 DQ895801 ABM86727 NM_004892 NP_004883
|
| Function |
SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
|
| Top Pathways |
Phagosome, Legionellosis, SNARE interactions in vesicular transport
|
