| Gene Symbol | C2 |
|---|---|
| Entrez Gene | 717 |
| Alt Symbol | ARMD14, CO2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | complement component 2 |
| Other Description | C3/C5 convertase|complement C2|complement component C2 |
| Swissprots | Q13904 B4DPF3 P06681 E9PFN7 B4DV20 O19694 |
| Accessions | AAA51854 AAA59624 AAA59649 AAB67975 AAB97607 AAQ15273 BAB63292 CAA54545 EAX03548 EAX03549 P06681 AA740316 AK096258 BAG53241 AK222537 BAD96257 AK222783 BAD96503 AK298311 BAG60565 AK298808 BAG60943 AK300892 BAG62532 AK300930 BAG62560 AK307930 AK312581 BAG35475 AW515583 BC029781 AAH29781 BC043484 AAH43484 BX537504 CAD97767 DC349268 DC358441 DC362624 N63977 X04481 CAA28169 NM_000063 NP_000054 NM_001145903 NP_001139375 NM_001178063 NP_001171534 NM_001282457 NP_001269386 NM_001282458 NP_001269387 NM_001282459 NP_001269388 |
| Function | Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. |
| Subcellular Location | Secreted. |
| Top Pathways | Complement and coagulation cascades, Systemic lupus erythematosus, Staphylococcus aureus infection, Pertussis |