UBE2D2

Gene Symbol	UBE2D2
Entrez Gene	7322
Alt Symbol	E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2D 2
Other Description	p53-regulated ubiquitin-conjugating enzyme 1\|ubiquitin carrier protein D2\|ubiquitin-conjugating enzyme E2 D2\|ubiquitin-conjugating enzyme E2-17 kDa 2\|ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5)\|ubiquitin-protein ligase D2
Swissprots	Q96RP6 Q3MN78 D3DQC9 P62837
Accessions	AAC41750 EAW62095 EAW62096 EAW62097 P62837 AF317220 AAK93958 AK001311 BAG50891 AK001428 BAG50911 AK310273 AY651263 AAX35690 BC019052 BC033349 AAH33349 BC048426 BQ186099 U39317 AAA91460 XM_011537679 XP_011535981 NM_003339 NP_003330 NM_181838 NP_862821
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. {ECO:0000269\|PubMed:10329681, ECO:0000269\|PubMed:15280377, ECO:0000269\|PubMed:18042044, ECO:0000269\|PubMed:18359941, ECO:0000269\|PubMed:18703417, ECO:0000269\|PubMed:19854139, ECO:0000269\|PubMed:20061386, ECO:0000269\|PubMed:20403326, ECO:0000269\|PubMed:20525694}.
Top Pathways	Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

UBE2D2 (Y-20) - sc-100617 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

UBE2D2 (Y-20): sc-100617. Western blot analysis of UBE2D2 expression in NIH/3T3 whole cell lysate.

Anti-UBE2D2 antibody - ab66602 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-UBE2D2 antibody (ab66602) at 1.25 µg/ml (in 5% skim milk / PBS buffer) + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-UBE2D2 antibody - ab125946 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-UBE2D2 antibody (ab125946) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 3 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 4 : NIH 3T3 (Mouse embryonic fibroblast cell line) Whole Cell Lysate Lane 5 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 6 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-UBE2D2 antibody - ab106314 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-UBE2D2 antibody (ab106314) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate Lane 3 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 4 : NIH 3T3 (Mouse embryonic fibroblast cell line) Whole Cell Lysate Lane 5 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 6 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-UBE2D2 antibody - ab58248 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-UBE2D2 antibody - ab123573 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-UBE2D2 antibody (ab123573) at 1/100 dilution + 293 cell line lysate at 35 µg

Anti-UBE2D2 antibody [EPR11031(B)] - ab155088 from Abcam

Prices	$99.00, $357.00
Sizes	10 µl, 100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR11031(B)

All lanes : Anti-UBE2D2 antibody [EPR11031(B)] (ab155088) at 1/1000 dilutionLane 1 : MCF7 cell lysateLane 2 : HeLa cell lysateLane 3 : 293T cell lysateLane 4 : Human fetal brain lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-UBE2D2 antibody [EPR11032(B)] - ab155285 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR11032(B)

All lanes : Anti-UBE2D2 antibody [EPR11032(B)] (ab155285) at 1/1000 dilutionLane 1 : MCF7 cell lysateLane 2 : Human fetal brain lysateLane 3 : HeLa cell lysateLane 4 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-UBE2D2 antibody - N-terminal - ab202345 from Abcam

Prices	$359.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-UBE2D2 antibody - N-terminal (ab202345) at 1/1000 dilutionLane 1 : HeLa cell line lysateLane 2 : SW480 cell line lysateLane 3 : NIH3T3 cell line lysateLane 4 : Rat testis tissue lysateLysates/proteins at 35 µg per lane.SecondaryGoat anti-rabbit IgG H&L(HRP) at 1/10000 dilution

Anti-UBE2D2 / UBCH5B Antibody (clone 1D11) - LS-C340030 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1D11

IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-UBE2D2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-UBE2D2 / UBCH5B Antibody (clone 2C2) - LS-C340028 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2C2

IHC of paraffin-embedded Human endometrium tissue using anti-UBE2D2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-UBE2D2 / UBCH5B Antibody (aa112-140, AP) - LS-C272861 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-UBE2D2 / UBCH5B Antibody (aa112-140, APC) - LS-C272862 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-UBE2D2 / UBCH5B Antibody (N-Terminus) - LS-C110741 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

UBE2D2 antibody LS-C110741 Western blot of Fetal Brain lysate.

Anti-UBE2D2 / UBCH5B Antibody (aa91-140) - LS-C31942 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

UBE2D2 antibody LS-C31942 was used in IHC to stain formalin-fixed, paraffin-embedded human lung.

Anti-UBE2D2 / UBCH5B Antibody (aa112-140, Biotin) - LS-C272863 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-UBE2D2 / UBCH5B Antibody (aa112-140, FITC) - LS-C272864 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-UBE2D2 / UBCH5B Antibody (aa112-140, PE) - LS-C272865 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-UBE2D2 / UBCH5B Antibody (aa112-140, Azide-free, HRP) - LS-C272866 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-UBE2D2 / UBCH5B Antibody (aa36-85) - LS-C110742 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

UBE2D2 antibody LS-C110742 Western blot of Fetal Liver lysate.

Anti-UBE2D2 / UBCH5B Antibody (aa90-139) - LS-C292208 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-UBE2D2 / UBCH5B Antibody (aa102-147) - LS-C313986 from LifeSpan Bioscience

Prices	$345.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-UBE2D2 / UBCH5B Antibody (aa111-140) - LS-C326128 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-UBE2D2 / UBCH5B Antibody (clone 1A9) - LS-C339997 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1A9

IHC of paraffin-embedded Human tonsil using anti-UBE2D2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-UBE2D2 / UBCH5B Antibody (clone 1D2) - LS-C339989 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1D2

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY UBE2D2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-UBE2D2.

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