RORC

Gene Symbol	RORC
Entrez Gene	6097
Alt Symbol	NR1F3, RORG, RZR-GAMMA, RZRG, TOR
Species	Human
Gene Type	protein-coding
Description	RAR-related orphan receptor C
Other Description	RAR-related orphan nuclear receptor variant 2|nuclear receptor ROR-gamma|nuclear receptor RZR-gamma|nuclear receptor subfamily 1 group F member 3|retinoic acid-binding receptor gamma|retinoid-related orphan receptor gamma
Swissprots	P51449 Q5SZR9 Q8N5V7 Q8NCY8
Accessions	EAW53405 EAW53406 P51449 AB307696 BAH02287 AF075096 AK097994 BAG53561 AK128522 AK223137 BAD96857 AK298460 BAG60673 AK315662 BAG38028 AL834219 CAD38900 AM393818 CAL38693 AM393876 CAL38751 AW004872 BC031554 AAH31554 BC110571 AAI10572 BI520481 CB161467 CR457436 CAG33717 DQ890805 ABM81731 DQ893960 ABM84886 HQ692834 ADZ17345 U16997 AAA64751 XM_006711484 XP_006711547 XR_426792 NM_001001523 NP_001001523 NM_005060 NP_005051
Function	Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25- hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue- selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, C
Subcellular Location	Nucleus {ECO:0000305}.
Tissue Specificity	Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2 is primarily expressed in immature thymocytes.
Top Pathways	Circadian rhythm, Inflammatory bowel disease (IBD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RORγ (D-4) - sc-365476 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

RORγ (27.92) - sc-293150 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

RORγ (G-16) - sc-26412 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

RORγ (H-190) - sc-28559 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

RORγ (K-20) - sc-14196 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

RORγ (S-14) - sc-26411 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

RORγ (162C2a) - sc-81371 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-ROR gamma antibody - ab78007 from Abcam Prices $384.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ROR gamma antibody - ab80690 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ROR gamma antibody - ab113434 from Abcam Prices $376.00 Sizes 200 µl Host Goat Clonality Polyclonal

Anti-ROR gamma antibody - ab74703 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ROR gamma antibody - ab138043 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ROR gamma antibody - ab137775 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ROR gamma antibody [162C2a] - ab58670 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 162C2a

Anti-ROR gamma antibody [4G419] (Phycoerythrin) - ab104950 from Abcam Prices $376.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 4G419

Anti-ROR gamma antibody [4G419], prediluted (FITC) - ab104906 from Abcam Prices $376.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 4G419

Anti-ROR gamma antibody [EPR13056] - ab180173 from Abcam Prices $385.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR13056

Anti-ROR gamma antibody [H6437] - ab41941 from Abcam Host Mouse Clonality Monoclonal Clone H6437

Anti-RORC / ROR Gamma Antibody (aa212-461) - LS-C296184 from LifeSpan Bioscience Prices $405.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RORC / ROR Gamma Antibody (clone 1G7) - LS-C198102 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1G7

Anti-RORC / ROR Gamma Antibody (Internal) - LS-C345259 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RORC / ROR Gamma Antibody (aa1-50) IHC-plus™ - LS-B1797 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RORC / ROR Gamma Antibody (aa1-50, clone 4G419) - LS-C148460 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4G419

Anti-RORC / ROR Gamma Antibody (clone 162C2a) - LS-C342609 from LifeSpan Bioscience Prices $375.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 162C2a

Anti-RORC / ROR Gamma Antibody (Ligand-binding Domain) IHC-plus™ - LS-A5191 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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