NOTCH3

Gene Symbol NOTCH3
Entrez Gene 4854
Alt Symbol CADASIL, CASIL, IMF2
Species Human
Gene Type protein-coding
Description notch 3
Other Description Notch homolog 3|neurogenic locus notch homolog protein 3
Swissprots Q9UEB3 Q9Y6L8 Q9UM47 Q9UPL3
Accessions AAC04897 AAC14346 AAC15789 ACL52278 CAA55955 EAW84466 Q9UM47 AB209447 BAD92684 DQ156540 DQ156541 DQ156542 DQ156543 U97669 AAB91371 XM_005259924 XP_005259981 NM_000435 NP_000426
Function Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Ubiquitously expressed in fetal and adult tissues.
Top Pathways Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation

Notch3 Antibody - 2889 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A2780 and HBP-ALL cells using Notch3 Antibody.

Notch3 (D11B8) Rabbit mAb - 5276 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D11B8
Western blot analysis of extracts from various cell lines using Notch3 (D11B8) Rabbit mAb.

Notch3 (8G5) Rat mAb - 3446 from Cell Signaling Technology

Prices $256.00
Sizes 100 µl (10 western blots)
Host Rat
Clonality Monoclonal
Clone 8G5
Western blot analysis of extracts from HBP-ALL and A204 cells using Notch3 (8G5) Rat mAb. Full-length (FL) and cleaved notch3 proteins are indicated.

Notch 3 (M-134) - sc-5593 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Notch 3 (M-134): sc-5593. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse kidney tissue showing membrane and nuclear localization.

Notch 3 (M-20) - sc-7424 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Notch 3 (M-20): sc-7424. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse kidney tissue showing membrane and nuclear localization.

Anti-NOTCH3 antibody - ab23426 from Abcam

Prices $401.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NOTCH3 antibody (ab23426) at 1 µg/mlLane 1 : K562 (Human erythromyeloblastoid leukemia cell line) Whole Cell Lysate - tumor cell line (ab29306)Lane 2 : Caco 2 (Human colonic carcinoma cell line) Whole Cell Lysate (ab3950)Lane 3 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-NOTCH3 antibody - ab60087 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Ab60087 (1/50-1/100) staining human NOTCH3 in human cancer tissue by immunohistochemistry using formalin fixed, paraffin embedded tissue. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma.

Anti-NOTCH3 antibody - ab92758 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ab92758 at 1/100 dilution staining NOTCH3 in (Bergmann glia-10 micron cryostat sections) rat cerebellum by Immunohistochemistry.

Anti-NOTCH3 antibody - C-terminal - ab192006 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human Hippocampus tissue labeling NOTCH3 with ab192006 at 4 µg/ml.

Anti-NOTCH3 Antibody (aa2306-2321) - LS-C3048 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NOTCH3 Antibody (C-Terminus) - LS-C73705 from LifeSpan Bioscience

Prices $405.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-NOTCH3 Antibody (C-Terminus) - LS-C83739 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NOTCH3 Antibody (APC) - LS-C144078 from LifeSpan Bioscience

Prices $605.00
Sizes 100 tst
Host Sheep
Clonality Polyclonal

Anti-NOTCH3 Antibody (aa40-468) - LS-C150223 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-NOTCH3 Antibody (clone HMN3-133) - LS-C182624 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Hamster
Clonality Monoclonal
Clone HMN3-133

Anti-NOTCH3 Antibody (aa40-467, clone 12K144, APC) - LS-C182919 from LifeSpan Bioscience

Prices $635.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone 12K144

Anti-NOTCH3 Antibody (clone HMN3-133) - LS-C188664 from LifeSpan Bioscience

Prices $235.00
Sizes 100 µg
Host Hamster
Clonality Monoclonal
Clone HMN3-133

Anti-NOTCH3 Antibody (aa40-467, clone 12K144, PerCP) - LS-C182920 from LifeSpan Bioscience

Prices $605.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone 12K144

Anti-NOTCH3 Antibody (Internal) - LS-C210154 from LifeSpan Bioscience

Prices $295.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-NOTCH3 Antibody (C-Terminus, clone 487CT6.9.2, AP) - LS-C212508 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 487CT6.9.2

Anti-NOTCH3 Antibody (clone HMN3-133, PE) - LS-C106264 from LifeSpan Bioscience

Prices $245.00, $355.00
Sizes 25 µg, 100 µg
Host Hamster
Clonality Monoclonal
Clone HMN3-133
Staining of CD4+CD8+ (blue histogram) and CD4-CD8-CD25+CD44- (purple histogram) C57Bl/6 thymocytes with 0.5 ug of PE Armenian Hamster IgG isotype control (left) or 0.25 ug of PE anti-mouse Notch3 (right). Total viable cells were used for analysis.

Anti-NOTCH3 Antibody (C-Terminus, clone 487CT6.9.2, Biotin) - LS-C212509 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 487CT6.9.2

Anti-NOTCH3 Antibody (C-Terminus, clone 487CT6.9.2, FITC) - LS-C212510 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 487CT6.9.2

Anti-NOTCH3 Antibody (C-Terminus, clone 487CT6.9.2, Azide-free, HRP) - LS-C212511 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 487CT6.9.2

Anti-NOTCH3 Antibody (C-Terminus, AP) - LS-C220184 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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