| Gene Symbol |
TNFRSF17
|
| Entrez Gene |
608
|
| Alt Symbol |
BCM, BCMA, CD269, TNFRSF13A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tumor necrosis factor receptor superfamily, member 17
|
| Other Description |
B cell maturation antigen|B-cell maturation factor|B-cell maturation protein|tumor necrosis factor receptor superfamily member 17
|
| Swissprots |
Q02223 Q2TQ40
|
| Accessions |
AAB67251 AAR84240 BAB60895 CAA82690 CAJ90608 CAJ90610 EAW85129 Q02223 AY684975 AAV92616 BC058291 AAH58291 EF152353 ABN42508 EF152354 ABN42509 EF152355 ABN42510 EF152356 ABN42511 Z14954 CAA78679 Z29575 CAA82691 NM_001192 NP_001183
|
| Function |
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. {ECO:0000269|PubMed:10801128, ECO:0000269|PubMed:10903733, ECO:0000269|PubMed:10973284}.
|
| Subcellular Location |
Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures.
|
| Tissue Specificity |
Expressed in mature B-cells, but not in T- cells or monocytes.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production
|
![Western Blot: BCMA Overexpression Lysate (Adult Normal) [NBL1-17151] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for BCMA.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/26217_BCMA%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17151-img0002.jpg)