ABCB5

Gene Symbol ABCB5
Entrez Gene 340273
Alt Symbol ABCB5alpha, ABCB5beta, EST422562
Species Human
Gene Type protein-coding
Description ATP-binding cassette, sub-family B (MDR/TAP), member 5
Other Description ABCB5 P-gp|ATP-binding cassette protein|ATP-binding cassette sub-family B member 5|P-glycoprotein ABCB5
Swissprots Q6KG50 Q5I5Q8 Q5I5Q7 Q6XFQ5 Q2M3G0 B7WPL1 A7BKA4 B5MD19 F8QQP9 F8QQP8 Q8IXA1 Q2M3I5 A4D131 J3KQ04
Accessions EAL24273 EAL24274 EAW93726 EAW93727 Q2M3G0 AB353947 BAF75364 AF319622 AAN76500 AF399931 AAQ03033 AI334015 AK127141 AL040763 AY090613 AAM09027 AY230001 AAP55848 AY234788 AAO73470 AY785909 AAX11382 AY851364 AAW31629 AY851365 AAW31630 BC044248 BC104894 AAI04895 BC104920 AAI04921 BC110370 BM471690 BX452500 BX537763 GU437216 ADV32636 GU437217 ADV32637 H99394 XM_006715722 XP_006715785 XM_011515367 XP_011513669 XM_011515368 XP_011513670 NM_001163941 NP_001157413 NM_001163942 NP_001157414 NM_001163993 NP_001157465 NM_178559 NP_848654
Function Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair. {ECO:0000269|PubMed:12960149, ECO:0000269|PubMed:15205344, ECO:0000269|PubMed:15899824, ECO:0000269|PubMed:22306008}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12960149}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:12960149}.
Tissue Specificity Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium. {ECO:0000269|PubMed:12960149, ECO:0000269|PubMed:15760339, ECO:0000269|PubMed:22044138, ECO:0000269|PubMed:22675422, ECO:0000269|PubMed:22784549, ECO:0000269|PubMed:23770371, ECO:0000269|PubMed:24934811, ECO:0000269|PubMed:25030174}.
Top Pathways ABC transporters

ABCB5 (N-13) - sc-104019 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ABCB5 antibody - ab77549 from Abcam

Prices $379.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-ABCB5 antibody (ab77549) at 0.03 µg/ml + A431 cell lysate (in RIPA buffer) at 35 µg

Anti-ABCB5 antibody - ab203120 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded mouse melanoma tissue sections labeling ABCB5 with ab203120 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Anti-ABCB5 antibody - ab197406 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human renal cancer tissue labeling ABCB5 with ab197406 at a 1/10 dilution.

Anti-ABCB5 antibody - ab80108 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ABCB5 antibody (ab80108) at 1/50 dilution + K562 cell line lysates at 35 µg

Anti-ABCB5 antibody - ab126864 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal

Anti-ABCB5 antibody [5H3C6] - ab140667 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5H3C6
Flow cytometric analysis of HepG2 cells labeling ABCB5 with ab140667 at 1/200 dilution (green);negative control (red).

Anti-ABCB5 Antibody (aa364-378) - LS-C154903 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-ABCB5 Antibody (Biotin) - LS-C180804 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCB5 Antibody (DY650) - LS-C180805 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCB5 Antibody IHC-plus™ - LS-B6371 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-ABCB5 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6371 concentration 2.5 ug/ml.

Anti-ABCB5 Antibody (Internal) - LS-C154236 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC - ABCB5 Antibody. Immunohistochemistry of ABCB5 antibody tissue: human liver Fixation: formalin fixed paraffin embedded Antigen retrieval: user optimized Primary antibody: ABCB5 1:200 Secondary antibody: Peroxidase goat anti-rabbit at 1:10000 for 45 min at RT Localization: Moderate to strong cytoplasmic and membranous staining was observed in hepatocytes. Occasional nuclear staining was observed in hepatocytes and sinusoidal cells. Staining: antibody as precipitated red signal with a hematoxylin purple nuclear counterstain.

Anti-ABCB5 Antibody (DY488) - LS-C180806 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCB5 Antibody (aa905-916) - LS-C61699 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.03 ug/ml) staining of A431 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-ABCB5 Antibody (DY550) - LS-C180807 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCB5 Antibody (Biotin) - LS-C180813 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCB5 Antibody (DY488) - LS-C180815 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCB5 Antibody (DY550) - LS-C180816 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCB5 Antibody - LS-C180154 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: ABCB5 Antibody - ABCB5 antibody was tested in A431 cells with FITC (green). Nuclei were counterstained with DAPI (blue).

Anti-ABCB5 Antibody (DY650) - LS-C180814 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCB5 Antibody (aa141-247) - LS-C184169 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-ABCB5 Antibody - LS-C180152 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: ABCB5 Antibody - Analysis of ABCB5 in mouse spleen using DAB with hematoxylin counterstain.

Anti-ABCB5 Antibody (clone 5H3C6) - LS-C169144 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5H3C6
IHC of paraffin-embedded liver cancer tissues using ABCB5 mouse monoclonal antibody with DAB staining.

Anti-ABCB5 Antibody (aa1-30) IHC-plus™ - LS-B3454 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-ABCB5 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3454 concentration 10 ug/ml.

ABCB5 Antibody - NBP1-77687 from Novus Biologicals

Prices $99.00, $299.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: ABCB5 Antibody [NBP1-77687] - ABCB5 antibody was tested in A431 cells with FITC (green). Nuclei and actin were counterstained with DAPI (blue) and Phalloidin (red).
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