Tp53

Gene Symbol	Tp53
Entrez Gene	24842
Alt Symbol	Trp53, p53
Species	Rat
Gene Type	protein-coding
Description	tumor protein p53
Other Description	cellular tumor antigen p53|transformation related protein 53|tumor protein p53 (Li-Fraumeni syndrome)|tumor suppressor p53
Swissprots	Q4KMA9 O09168 Q66HM0 P10361
Accessions	AAA41788 AAF43277 AAF43278 AAG34052 AAG34053 EDM04871 EDM04872 EDM04873 P10361 AF209191 AAG35765 AY009504 AAG35178 BC081788 AAH81788 BC098663 AAH98663 CV126174 FQ232659 U90328 AAB80959 X13058 CAA31457 XM_006246594 XP_006246656 XM_006246595 XP_006246657 XM_008767773 XP_008765995 NM_030989 NP_112251
Function	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to e
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Mitochondrion matrix {ECO:0000269|PubMed:22726440}. Note=Interaction with BANP promotes nuclear localization. Translocates to mitochondria upon oxidative stress (By similarity). {ECO:0000250}.
Top Pathways	Measles, Epstein-Barr virus infection, Sphingolipid signaling pathway, Apoptosis, Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Rat Tp53 / Cellular Tumor Antigen p53 ELISA Kit - RAB0910 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Cellular tumor antigen p53, Tp53, Rat, ELISA Kit - E0928r from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

P53/tumor protein, p53/TP53, Rat, ELISA Kit - CSB-E08336r from ARP American Research Products Category ELISA Kit Prices $586.00, $856.00, $858.00, $860.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.12 pg/ml Range 12.5 pg/ml-800 pg/ml

Rat TP53(Tumor Protein p53) ELISA Kit - E-EL-R1042 from Elabscience Category ELISA Kit Sensitivity 46.88 pg/mL Range 78.13—5000 pg/mL

Rat TP53 (Tumor Protein 53) CLIA Kit - E-CL-R0677 from Elabscience Category CLIA Kit Sensitivity 9.38 pg/mL Range Average Recovery (%)

Mutant type p53, ELISA Kit - MBS744523 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Mutant type p53, ELISA Kit - MBS729682 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mutant type p53, ELISA Kit - MBS747102 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mutant type p53, ELISA Kit - MBS755297 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mutant type p53, ELISA Kit - MBS748642 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mutant type p53, ELISA Kit - MBS745334 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Mutant type p53, ELISA Kit - MBS723327 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mutant type p53, ELISA Kit - MBS733060 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Mutant type p53, ELISA Kit - MBS722842 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mutant type p53, ELISA Kit - MBS731843 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mutant type p53, ELISA Kit - MBS749014 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mutant type p53, ELISA Kit - MBS751331 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rat p53/tumor protein,p53/TP53 ELISA Kit - CSB-E08336r from Cusabio Category ELISA Kit Sensitivity 3.12pg/ml Range 12.5 pg/ml-800 pg/ml

Rat TP53(Tumor Protein p53) ELISA Kit - E-EL-R1042 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 46.88 pg/mL Range 78.13~5000 pg/mL

Rat TP53 (Tumor Protein 53) CLIA Kit - E-CL-R0677 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 46.875pg/mL Range 78.125-5000pg/mL

Rat Cellular tumor antigen p53 ELISA Kit - abx256372 from Abbexa Category ELISA Kit Range 78.125 pg/ml - 5000 pg/ml

Rat TP53 / p53 Mutant ELISA Kit (Sandwich ELISA) - LS-F24092 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 46.875 pg/ml Range 62.5-4000 pg/ml

Tumor Protein p53 (TP53), Rat, ELISA Kit - DL-TP53-Ra from ARP American Research Products Category ELISA Kit Prices $715.00 Sizes 96 t Range 78-5,000 pg/mL

Rat TP53 ELISA Kit - abx576271 from Abbexa Category ELISA Kit Sensitivity 28 pg/ml Range 78.125 pg/ml - 5000 pg/ml

Rat Cellular tumor antigen p53 ELISA Kit - EKE53704 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Range 0.156-10 ng/mL

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