| Gene Symbol |
Mfge8
|
| Entrez Gene |
17304
|
| Alt Symbol |
AA408458, AI325141, MFG-E8, MP47, Mfgm, P47, SED1, lactadherin
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
milk fat globule-EGF factor 8 protein
|
| Other Description |
EGF/factor VIII|lactadherin|milk fat globule glycoprotein|sperm surface protein SP47
|
| Swissprots |
Q3U8S9 Q9R1X9 Q3TBN5 P97800 P21956 Q9WTS3
|
| Accessions |
BAA36214 EDL07075 EDL07076 EDL07077 P21956 AB021130 BAA35180 AB025280 BAA76386 AK087555 AK089211 BAC40794 AK145183 AK148371 BAE28512 AK152088 BAE30938 AK155047 AK169997 BAE41503 AK170935 BAE42127 AK171143 BAE42274 AK178722 AK179489 AK181224 AK182601 AK185944 AK189618 AK189622 AK190455 AK190819 AK192581 AK193016 AK193609 AK193753 AK193868 AK194123 AK194145 AK194326 AK194803 AK195127 AK195377 AK195556 AK195675 AK196442 AK196948 AK197795 AK199381 AK200279 AK200283 AK200528 AK200809 AK200926 AK201191 AK202028 AK202981 AK203389 AK204233 AK204253 AK204278 AK205061 AK205167 AK206323 AK206818 AK206986 AK207561 AK207636 AK209209 AK210333 AK210816 AK212128 AK212659 AK213407 AK214404 AK218369 AK219560 AK219564 AK219710 BC003892 AAH03892 BC003904 AAH03904 BC018577 BC037475 CD776821 M38337 AAA39534 Y11684 CAA72380 NM_001045489 NP_001038954 NM_008594 NP_032620
|
| Function |
Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha- v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction (By similarity). Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. {ECO:0000250, ECO:0000269|PubMed:15834428, ECO:0000269|PubMed:18008006}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:2122462}; Peripheral membrane protein {ECO:0000269|PubMed:2122462}. Secreted {ECO:0000269|PubMed:2122462}.
|
| Tissue Specificity |
Mammary epithelial cell surfaces and spermatozoan. Isoform 2 is present in brain, heart, kidney and spleen and at low levels in lung, liver, small intestine and testis. {ECO:0000269|PubMed:2122462, ECO:0000269|PubMed:9920772}.
|