| Gene Symbol | LIAS |
|---|---|
| Entrez Gene | 11019 |
| Alt Symbol | HUSSY-01, LAS, LIP1, LS, PDHLD |
| Species | Human |
| Gene Type | protein-coding |
| Description | lipoic acid synthetase |
| Other Description | LS|lip-syn|lipoate synthase|lipoyl synthase, mitochondrial |
| Swissprots | Q8IV62 C9JCF6 O43766 A8K873 |
| Accessions | CBN72404 CBN72413 EAW92932 EAW92933 EAW92934 O43766 AI373464 AJ224162 CAA11859 AK026289 AK291985 BAF84674 AK292238 BAF84927 AK303429 BAG64479 AL528262 AV729111 BC023635 AAH23635 BC062751 AAH62751 BF434814 HQ447772 ADQ32257 XM_006713990 XP_006714053 NM_001278590 NP_001265519 NM_001278591 NP_001265520 NM_001278592 NP_001265521 NM_006859 NP_006850 NM_194451 NP_919433 |
| Function | Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. {ECO:0000255|HAMAP-Rule:MF_03123}. |
| Subcellular Location | Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03123}. |
| Top Pathways | Lipoic acid metabolism |