| Gene Symbol |
KAT7
|
| Entrez Gene |
11143
|
| Alt Symbol |
HBO1, HBOA, MYST2, ZC2HC7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
K(lysine) acetyltransferase 7
|
| Other Description |
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2|MYST histone acetyltransferase 2|MYST-2|histone acetyltransferase KAT7|histone acetyltransferase MYST2|histone acetyltransferase binding to ORC1|lysine acetyltransferase 7
|
| Swissprots |
B4DFB4 G5E9K7 B4DGY4 B3KN74 E7ER15 O95251 B4DF85 B4DFE0
|
| Accessions |
EAW94658 EAW94659 EAW94660 EAW94661 O95251 AF074606 AAC99368 AF140360 AAD42348 AF217502 AAL56649 AK023890 BAG51236 AK122932 BAG53804 AK293976 BAG57346 AK294014 BAG57375 AK294052 BAG57401 AK294367 BAG57629 AK294602 BAG57789 AK294836 BAG57945 AK295914 BAG58702 AK297212 BAH12525 BC015485 BC032640 AAH32640 DC306552 DQ890883 ABM81809 DQ894037 ABM84963 XM_011524235 XP_011522537 NM_001199155 NP_001186084 NM_001199156 NP_001186085 NM_001199157 NP_001186086 NM_001199158 NP_001186087 NM_007067 NP_008998
|
| Function |
Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription. {ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:10930412, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653}.
|
| Subcellular Location |
Nucleus, nucleoplasm {ECO:0000269|PubMed:10930412, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653}.
|
| Tissue Specificity |
Ubiquitously expressed, with highest levels in testis. {ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:10930412}.
|
