| Gene Symbol |
MTRR
|
| Entrez Gene |
4552
|
| Alt Symbol |
MSR, cblE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
|
| Other Description |
[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing)|methionine synthase reductase|methionine synthase reductase, mitochondrial
|
| Swissprots |
Q32MA9 Q9UBK8 Q7Z4M8 O60471
|
| Accessions |
AAF17303 AAF17304 EAX08090 EAX08091 EAX08092 EAX08093 Q9UBK8 AF025794 AAC39667 AF121214 AAF16876 AK308442 AK311663 BC035977 BC054816 AAH54816 BC062577 BC109216 AAI09217 BC109217 XM_006714474 XP_006714537 XM_011514043 XP_011512345 XM_011514044 XP_011512346 XM_011514045 XP_011512347 XR_241702 XR_241703 XR_925614 XR_925615 NM_002454 NP_002445 NM_024010 NP_076915
|
| Function |
Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effects. {ECO:0000269|PubMed:17892308}.
|
| Subcellular Location |
Isoform A: Cytoplasm {ECO:0000269|PubMed:18221906}.
|
| Tissue Specificity |
Found in all tissues tested, particularly abundant in skeletal muscle.
|