BMPR2

Gene Symbol	BMPR2
Entrez Gene	659
Alt Symbol	BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK
Species	Human
Gene Type	protein-coding
Description	bone morphogenetic protein receptor, type II (serine/threonine kinase)
Other Description	BMP type II receptor|BMP type-2 receptor|BMPR-2|bone morphogenetic protein receptor type II|bone morphogenetic protein receptor type-2|type II activin receptor-like kinase|type II receptor for bone morphogenetic protein-4
Swissprots	Q53SA5 Q13161 Q16569 Q4ZG08 Q13873 Q585T8
Accessions	AAX76517 AAX88941 AAY24146 EAW70309 EAW70310 Q13873 AK023426 AK093832 AK123579 AK292430 BAF85119 AY277593 AAQ18032 BC018743 BC032011 BC035097 BC041039 BC043650 BC052985 AAH52985 BF063564 BG530017 BQ889263 BQ896556 BU176845 C15977 D50516 BAA09094 DA787547 DB233604 U20165 AAC50105 Z48923 CAA88759 XM_011511687 XP_011509989 XM_011511688 XP_011509990 NM_001204 NP_001195 NM_033346
Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Highly expressed in heart and liver.
Top Pathways	Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, MicroRNAs in cancer, Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BMPR2 overexpression lysate - LY420077 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

BMPR2 293 Cell Lysate - 409403 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Tissue Bone

BMPR-II Overexpression Lysate (Native) - NBL1-08009 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

BMPR2 Over-expression Lysate Product - GWB-CB3579 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Human BMPR2 / BMPR-II HEK293 Cell Lysate (WB positive control) - 10551-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human BMPR2 / BMPR-II HEK293 Cell Lysate (WB positive control) - 10551-H03HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human BMPR-II Human Cells Transfected Lysate (positive control) (denatured) - orb173130 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

BMPR-II Overexpression Lysate (Denatured) - H00000659-T02 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Human BMPR-II Human Cells Transfected Lysate (positive control) (denatured) - orb172791 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human BMPR2 Knockdown Stable Cell Line - CSC-DC001481 from Creative biogene Category Cell Line Species Human

BMPR2 Knockout Cell Line-HeLa - CSC-RT1928 from Creative biogene Category Cell Line Species Human

BMPR2 KO Cell Lysate-HeLa - CLKO-1784 from Creative biogene Category Cell Lysate

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