GDF5

Gene Symbol	GDF5
Entrez Gene	8200
Alt Symbol	BDA1C, BMP-14, BMP14, CDMP1, LAP-4, LAP4, OS5, SYM1B, SYNS2
Species	Human
Gene Type	protein-coding
Description	growth differentiation factor 5
Other Description	CDMP-1|LPS-associated protein 4|bone morphogenetic protein 14|cartilage-derived morphogenetic protein-1|growth/differentiation factor 5|lipopolysaccharide-associated protein 4|radotermin
Swissprots	Q96SB1 E1P5Q2 P43026
Accessions	ADD39269 ADD39270 ADD39271 ADD39272 ADD39273 ADD39274 ADD39275 ADD39276 ADD39277 ADD39278 ADD39279 ADD39280 ADD39281 ADD39282 ADD39283 ADD39284 ADD39285 ADD39286 ADD39287 ADD39288 ADD39289 ADD39290 ADD39291 ADD39292 ADD39293 ADD39294 ADD39295 ADD39296 ADD39297 ADD39298 ADD39299 ADD39300 ADD39301 ADD39302 ADD39303 ADD39304 ADD39305 ADD39306 ADD39307 ADD39308 ADD39309 ADD39310 ADD39311 ADD39312 ADD39313 ADD39314 ADD39315 ADD39316 ADD39317 ADD39318 ADD39319 ADD39320 ADD39321 ADD39322 ADD39323 ADD39324 ADD39325 ADD39326 ADD39327 ADD39328 ADD39329 ADD39330 ADD39331 ADD39332 ADD39333 ADD39334 ADD39335 ADD39336 ADD39337 ADD39338 ADD39339 ADD39340 ADD39341 ADD39342 ADD39343 ADD39344 ADD39345 ADD39346 ADD39347 ADD39348 ADD39349 ADD39350 ADD39351 ADD39352 ADD39353 ADD39354 ADD39355 ADD39356 ADD39357 ADD39358 ADD39359 ADD39360 ADD39361 ADD39362 ADD39363 ADD39364 ADD39365 ADD39366 ADD39367 ADD39368 ADD39369 ADD39370 ADD39371 ADD39372 ADD39373 ADD39374 ADD39375 ADD39376 ADD39377 ADD39378 ADD39379 ADD39380 ADD39381 ADD39382 ADD39383 ADD39384 ADD39385 ADD39386 ADD39387 ADD39388 ADD39389 ADD39390 ADD39391 ADD39392 ADD39393 ADD39394 ADD39395 ADD39396 ADD39397 ADD39398 ADD39399 ADD39400 ADD39401 ADD39402 ADD39403 ADD39404 ADD39405 ADD39406 ADD39407 ADD39408 ADD39409 ADD39410 ADD39411 ADD39412 ADD39413 ADD39414 ADD39415 ADD39416 ADD39417 ADD39418 ADD39419 ADD39420 ADD39421 ADD39422 ADD39423 ADD39424 ADD39425 ADD39426 ADD39427 ADD39428 ADD39429 ADD39430 ADD39431 ADD39432 ADD39433 ADD39434 ADD39435 ADD39436 ADD39437 ADD39438 ADD39439 ADD39440 ADD39441 ADD39442 ADD39443 ADD39444 ADD39445 ADD39446 ADD39447 ADD39448 ADD39449 ADD39450 ADD39451 ADD39452 ADD39453 ADD39454 ADD39455 ADD39456 ADD39457 ADD39458 ADD39459 ADD39460 ADD39461 ADD39462 ADD39463 ADD39464 ADD39465 ADD39466 ADD39467 ADD39468 ADD39469 ADD39470 ADD39471 ADD39472 ADD39473 ADD39474 ADD39475 ADD39476 ADD39477 ADD39478 ADD39479 ADD39480 ADD39481 ADD39482 ADD39483 ADD39484 ADD39485 ADD39486 ADD39487 ADD39488 ADD39489 ADD39490 ADD39491 ADD39492 ADD39493 ADD39494 ADD39495 ADD39496 ADD39497 ADD39498 ADD39499 ADD39500 ADD39501 ADD39502 ADD39503 ADD39504 ADD39505 ADD39506 ADD39507 ADD39508 ADD39509 ADD39510 ADD39511 ADD39512 ADD39513 ADD39514 ADD39515 ADD39516 ADD39517 ADD39518 ADD39519 ADD39520 ADD39521 ADD39522 ADD39523 ADD39524 ADD39525 ADD39526 ADD39527 ADD39528 ADD39529 ADD39530 ADD39531 ADD39532 ADD39533 ADD39534 ADD39535 ADD39536 ADD39537 ADD39538 ADD39539 ADD39540 ADD39541 ADD39542 ADD39543 ADD39544 ADD39545 ADD39546 ADD39547 ADD39548 ADD39549 ADD39550 ADD39551 ADD39552 BAA86941 CAA02710 CAA03553 CAA56874 CAB89416 CAI61691 CAL40861 CAL69822 CAL85395 CAP40148 CAS92879 CAT68524 CAT82626 CAX48923 EAW76208 EAW76209 P43026 AB593125 BAJ84065 BC032495 AAH32495 BC111566 AAI11567 BC111859 AAI11860 BU625224 EU832171 ACE87521 HQ257975 ADR82729 U13660 AAA57007 XM_011529075 XP_011527377 XM_011529076 XP_011527378 NM_000557 NP_000548
Function	Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. {ECO:0000250, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:15530414, ECO:0000269|PubMed:19229295}.
Subcellular Location	Secreted {ECO:0000269|PubMed:11276205}. Cell membrane {ECO:0000269|PubMed:11276205}.
Tissue Specificity	Predominantly expressed in long bones during embryonic development. Expressed in monocytes (at protein level). {ECO:0000269|PubMed:11276205}.
Top Pathways	Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active mouse GDF 5 full length protein - ab129148 from Abcam Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Mouse

Human GDF 5 full length protein - ab52315 from Abcam Category Protein Source E. coli Species Human

Human GDF 5 full length protein - ab55329 from Abcam Category Protein Source E. coli Species Human

Human GDF 5 full length protein - ab86692 from Abcam Category Protein Source E. coli Species Human

Human GDF 5 peptide - ab105626 from Abcam Category Peptide

Mouse GDF 5 full length protein - ab119822 from Abcam Category Protein Source E. coli Species Mouse

Mouse GDF 5 full length protein - ab187449 from Abcam Category Protein Source E. coli Species Mouse

GDF5 / GDF-5 Antibody Blocking Peptide - LS-E1382 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GDF5 / GDF-5 Antibody Blocking Peptide - LS-E6847 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GDF-5/BMP-14 Protein - NBC1-28770 from Novus Biologicals Category Protein Prices $299.00 Sizes 100 µg Source E.coli Species Human

GDF-5/BMP-14 Recombinant Protein - P4100 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

GDF-5/BMP-14 Recombinant Protein - P4393 from Novus Biologicals Category Protein Prices $549.00 Sizes 50 µg Species Human

GDF-5/BMP-14 Protein - NBP1-99134 from Novus Biologicals Category Protein Species Human

Recombinant Human GDF-5/BMP-14 Protein - NBP1-99285 from Novus Biologicals Category Protein Prices $190.00 Sizes 50 µg Source E. coli Species Human

Recombinant Human GDF-5/BMP-14 Protein - NBP1-99148 from Novus Biologicals Category Protein Prices $80.00 Sizes 10 µg Source E. coli Species Human

GDF-5/BMP-14 Protein - NBP1-99379 from Novus Biologicals Category Protein Species Human

GDF-5/BMP-14 Recombinant Protein - P3399 from Novus Biologicals Category Protein Prices $549.00 Sizes 100 µg Species Human

GDF5-Antibody-C-term-Blocking-peptide - BP12038b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GDF5-Antibody-N-term-Blocking-Peptide - BP2067a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GDF5 recombinant protein - GTX65287 from GeneTex Category Protein Prices $199.00 Sizes 10 μg Source E. coli Species Human

GDF5 recombinant protein - GTX65286 from GeneTex Category Protein Prices $249.00 Sizes 50 μg Source E. coli Species Human

GDF5 recombinant protein - GTX53875 from GeneTex Category Protein Prices $199.00 Sizes 50 μg Source E. Coli

GDF5 recombinant protein - GTX65288 from GeneTex Category Protein Prices $249.00 Sizes 50 μg Source E. coli Species Human

Recombinant Human GDF-5, CF - 8340-G5-050 from R&D Systems Category Protein Source E. coli-derived, Ala382-Arg501

GDF5 Protein (OPPA00701) - OPPA00701 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

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