HMGCL

Gene Symbol HMGCL
Entrez Gene 3155
Alt Symbol HL
Species Human
Gene Type protein-coding
Description 3-hydroxymethyl-3-methylglutaryl-CoA lyase
Other Description 3-hydroxy-3-methylglutarate-CoA lyase|3-hydroxy-3-methylglutaryl-CoA lyase|3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase|HMG-CoA lyase|hydroxymethylglutaricaciduria|hydroxymethylglutaryl-CoA lyase, mitochondrial|mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase
Swissprots Q96FP8 B7UCC6 D3Y5K7 B4DUP4 P35914 Q6IBC0
Accessions AER36554 EAW95094 EAW95095 EAW95096 EAW95097 P35914 AI202943 AK122801 BAG53736 AK300733 BAG62406 AK309129 AK313869 BAG36597 BC010570 AAH10570 BC021145 BM981610 BT009792 AAP88794 CA306929 CR456884 CAG33165 DA425822 DQ892083 ABM83009 DQ895276 ABM86202 FJ472654 ACK58684 GU433941 ADD21697 L07033 AAA92733 NM_000191 NP_000182 NM_001166059 NP_001159531
Function Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. {ECO:0000269|PubMed:22847177, ECO:0000269|PubMed:22865860, ECO:0000269|PubMed:8566388}.
Subcellular Location Mitochondrion matrix. Peroxisome. Note=Unprocessed form is peroxisomal.
Tissue Specificity Highest expression in liver. Expressed in pancreas, kidey, intestine, testis, fibroblasts and lymphoblasts. Very low expression in brain and skeletal muscle. The relative expression of isoform 2 (at mRNA level) is highest in heart (30%), skeletal muscle (22%), and brain (14%). {ECO:0000269|PubMed:21952825}.
Top Pathways Peroxisome, Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism

HMGCL-Over-expression-Lysate - LY12610a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag HMGCL (arrow) using his tag antibody. 293T cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the HMGCL gene

HMGCL overexpression lysate - LY431216 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

HMGCL 293 Cell Lysate - 410303 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

HMGCL Overexpression Lysate (Native) - NBL1-11617 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: HMGCL Overexpression Lysate (Adult Normal) [NBL1-11617] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HMGCL.

HMGCL (h): 293 Lysate - sc-111008 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

HMGCL Over-expression Lysate Product - GWB-62D11D from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

HMGCL Overexpression Lysate (Denatured) - H00003155-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human HMGCL Knockdown Stable Cell Line - CSC-DC007120 from Creative biogene

Category Cell Line
Species Human
Search more