JAK2

Gene Symbol JAK2
Entrez Gene 3717
Alt Symbol JTK10, THCYT3
Species Human
Gene Type protein-coding
Description Janus kinase 2
Other Description JAK-2|Janus kinase 2 (a protein tyrosine kinase)|tyrosine-protein kinase JAK2
Swissprots O14636 O60674 O75297
Accessions AAY16348 ABK91947 ABM69254 ABX71217 EAW58774 O60674 AF001362 AAC23653 AF005216 AAB82092 AF058925 AAC23982 AI923337 AK292525 BAF85214 AK302618 BAG63863 AK308668 AY973034 AAY22962 BC039695 AAH39695 BC043187 NM_004972 NP_004963
Function Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosp
Subcellular Location Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:19783980}. Nucleus {ECO:0000269|PubMed:19783980}.
Tissue Specificity Ubiquitously expressed throughout most tissues. {ECO:0000269|PubMed:16424865}.
Top Pathways Toxoplasmosis, Leishmaniasis, Jak-STAT signaling pathway, Measles, Influenza A

Jak2 (D2E12) XP ® Rabbit mAb (PE Conjugate) - 5941 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D2E12
Flow cytometric analysis of K-562 cells using Jak2 (D2E12) XP ® Rabbit mAb (PE Conjugate) (green) compared to concentration-matched Rabbit (DA1E) mAb IgG XP ® Isotype Control (PE Conjugate) #5742 (red).

Jak2 (D2E12) XP ® Rabbit mAb (Biotinylated) - 4040 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2E12
Western blot analysis of extracts from various cell lines using Jak2 (D2E12) XP ® Rabbit mAb (Biotinylated) and detected with Streptavidin-HRP #3999.

Phospho-Jak2 (Tyr1008) (D4A8) Rabbit mAb (PE Conjugate) - 8149 from Cell Signaling Technology

Host Rabbit
Clonality Monoclonal
Clone D4A8

Phospho-Jak2 (Tyr1007) (D15E2) Rabbit mAb - 4406 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D15E2
Western blot analysis of extracts from UT-7 cells, untreated or treated with erythropoietin (EPO; 3 units/ml; 5 min) and from untreated HEL cells, using Phospho-Jak2 (Tyr1007) (D15E2) Rabbit mAb (upper) or total Jak2 (D2E12) Rabbit mAb #3230 (lower). HEL cells contain a V617F activating mutation in Jak2.

Phospho-Jak2 (Tyr221) Antibody - 3774 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from BaF3 cells, untreated or treated with IL-3 (5 minutes), using Phospho-Jak2 (Tyr221) Antibody #3774 (top) or total Jak2 (D2E12) XP ® Rabbit mAb #3230 (bottom).

Phospho-Jak2 (Tyr1007/1008) (C80C3) Rabbit mAb - 3776 from Cell Signaling Technology

Prices $297.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C80C3
Western blot analysis of extracts from UT-7 and BaF3 cells, untreated or treated with GM-CSF or IL-3 (5 minutes), using Phospho-Jak2 (Tyr1007/1008) (C80C3) Rabbit mAb #3776 (top) or total Jak2 (D2E12) XP ® Rabbit mAb #3230 (bottom).

Phospho-Jak2 (Tyr1008) (D4A8) Rabbit mAb - 8082 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4A8
Western blot analysis of extracts from BaF3 cells, untreated or treated with Mouse Interleukin-3 (mIL-3) #8923 (10 ng/ml, 5 min), using Phospho-Jak2 (Tyr1008) (D4A8) Rabbit mAb (upper) or total Jak2 (D2E12) XP ® Rabbit mAb #3230 (lower).

Phospho-Jak2 (Tyr1007/1008) Antibody - 3771 from Cell Signaling Technology

Prices $287.00, $678.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from UT7 cells, untreated or treated with GM-CSF (5 min), and BaF3 cells, untreated or treated with IL-3 (5 min), using Phospho-Jak2 (Tyr1007/1008) Antibody #3771 (upper) or total Jak2 (D2E12) XP ® Rabbit mAb #3230 (lower).

Jak2 (D2E12) XP ® Rabbit mAb - 3230 from Cell Signaling Technology

Prices $109.00, $277.00, $658.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2E12
Western blot analysis of extracts from K-562 cells, transfected with 100 nM SignalSilence® Control siRNA (Unconjugated) #6568 (-) or Jak2 siRNA (+), using Jak2 (D2E12) XP ® Rabbit mAb #3230 and α-Tubulin (11H10) Rabbit mAb #2125. The Jak2 (D2E12) XP ® Rabbit mAb confirms silencing of Jak2 expression, while the α-Tubulin (11H10) Rabbit mAb is used to control for loading and specificity of Jak2 siRNA.

Jak2 Antibody - 3773 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Jak2 (24B11) Rabbit mAb - 3229 from Cell Signaling Technology

Host Rabbit
Clonality Monoclonal
Clone 24B11

JAK2 (C-14) - sc-34479 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
JAK2 (C-14)-R: sc-34479-R. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells.

JAK2 (C-10) - sc-390539 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
JAK2 (C-10): sc-390539. Western blot analysis of JAK2 expression in PDGF treated NIH/3T3 (A) and K-562 (B) whole cell lysates.

JAK2 (C-20) - sc-294 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
JAK2 (C-20): sc-294. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in tubules.

JAK2 (HR-758) - sc-278 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
JAK2 (HR-758): sc-278. Western blot analysis of JAK2 expression in CCRF-CEM (A), NIH/3T3 (B), HEL 92.1.7 (C), K-562 (D), Jurkat (E) and TF-1 (F) whole cell lysates.

JAK2 (M-126) - sc-7229 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
JAK2 (M-126): sc-7229. Western blot analysis of JAK2 expression in K-562 whole cell lysate.

JAK2 (N-17) - sc-34480 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
JAK2 (N-17): sc-34480. Western blot analysis of JAK2 expression in PDGF treated NIH/3T3 whole cell lysate.

p-JAK2 (Tyr 1007/Tyr 1008) - sc-21870 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-JAK2 (Tyr 1007/ Tyr 1008)-R: sc-21870-R. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing nuclear and cytoplasmic staining of glandular cells.

p-JAK2 (Tyr 1007) - sc-101717 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-JAK2 (Tyr 1007): sc-101717. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing membrane and cytoplasmic localization.

p-JAK2 (Tyr 221) - sc-101718 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-JAK2 (Tyr 221): sc-101718. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing membrane and cytoplasmic localization.

Anti-JAK2 (phospho Y1007 + Y1008) antibody - ab68268 from Abcam

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-JAK2 (phospho Y1007 + Y1008) antibody (ab68268) at 1/500 dilution + GH stimulated mouse liver tissue lysate

Anti-JAK2 (phospho Y1007 + Y1008) antibody (Biotin) - ab68270 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-JAK2 (phospho Y1007 + Y1008) antibody (Biotin) (ab68270) at 1/500 dilution + GH stimulated mouse liver tissue lysate

Anti-JAK2 (phospho Y1007 + Y1008) antibody [E132] - ab32101 from Abcam

Prices $394.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone E132
Anti-JAK2 (phospho Y1007 + Y1008) antibody [E132] (ab32101) at 1/50 dilution + immunoprecipitation pellets from Jurkat cell lysate

Anti-JAK2 (phospho Y1007) antibody - ab195055 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-JAK2 (phospho Y1007) antibody (ab195055) at 1/500 dilutionLane 1 : HT29 cell extract untreatedLane 2 : HT29 cell extract treated with IL-4

Anti-JAK2 (phospho Y1007) antibody - ab39396 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab39396 staining human JAK2 in breast carcinoma tissue by Immunohistochemistry, Paraffin embedded tissue.
Search more