| Gene Symbol |
GABRP
|
| Entrez Gene |
517459
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
gamma-aminobutyric acid (GABA) A receptor, pi
|
| Other Description |
GABA(A) receptor subunit pi|gamma-aminobutyric acid receptor subunit pi
|
| Swissprots |
Q5EA06
|
| Accessions |
DAA18056 Q5EA06 BC123810 BT020763 AAX08780 XR_813589 NM_001015618 NP_001015618
|
| Function |
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Top Pathways |
GABAergic synapse, Morphine addiction, Nicotine addiction, Retrograde endocannabinoid signaling, Neuroactive ligand-receptor interaction
|
