SETD1A

Gene Symbol SETD1A
Entrez Gene 9739
Alt Symbol KMT2F, Set1, Set1A
Species Human
Gene Type protein-coding
Description SET domain containing 1A
Other Description SET domain-containing protein 1A|hSET1A|histone-lysine N-methyltransferase SETD1A|lysine N-methyltransferase 2F|set1/Ash2 histone methyltransferase complex subunit SET1
Swissprots O15047 A6NP62 Q8TAJ6 Q6PIF3
Accessions CCO13810 O15047 AB002337 BAA20797 BC027450 AAH27450 BC035795 AAH35795 XM_005255723 XP_005255780 XM_006721106 XP_006721169 XM_011545994 XP_011544296 XM_011545995 XP_011544297 XM_011545996 XP_011544298 NM_014712 NP_055527
Function Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. {ECO:0000269|PubMed:12670868}.
Subcellular Location Nucleus speckle {ECO:0000269|PubMed:17355966}. Chromosome {ECO:0000269|PubMed:17355966}. Note=Localizes to a largely non- overlapping set of euchromatic nuclear speckles with SETD1B, suggesting that SETD1A and SETD1B each bind to a unique set of target genes.
Top Pathways Lysine degradation

Set1A CRISPR/Cas9 KO Plasmid (h) - sc-406841 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Set1A HDR Plasmid (h) - sc-406841-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Set1A Double Nickase Plasmid (h) - sc-406841-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Set1A Double Nickase Plasmid (h2) - sc-406841-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Set1A CRISPR Activation Plasmid (h) - sc-406841-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Set1A CRISPR Activation Plasmid (h2) - sc-406841-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Set1A Lentiviral Activation Particles (h) - sc-406841-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Set1A Lentiviral Activation Particles (h2) - sc-406841-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Set1A siRNA (h) - sc-76484 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Set1A shRNA Plasmid (h) - sc-76484-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Set1A shRNA (h) Lentiviral Particles - sc-76484-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SETD1A RNAi - H00009739-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU120071 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19165 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19165 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05559 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05559

SETD1A siRNA (Human) - CRH6507 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SETD1A - MBS8240200 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Setd1a (NM_014712.1) - SHH405572 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SETD1A(NM_014712.1) - SHR192642 from Creative biogene

Category siRNA
Species Reactivities Human

SETD1A shRNA Plasmid (Human) - CHH6507 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SETD1A miRNA 3'UTR clone - MiUTR1H-09310 from Creative biogene

Species Reactivities Human
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