| Gene Symbol |
Il17rd
|
| Entrez Gene |
171463
|
| Alt Symbol |
2810004A10Rik, AI428510, Sef, Sef-S
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
interleukin 17 receptor D
|
| Other Description |
IL-17 receptor D|IL-17RD|interleukin-17 receptor D|interleukin-17 receptor-like protein|mSef|sef homolog
|
| Swissprots |
B2RRY7 Q8K447 Q8R5J8 Q8JZL1
|
| Accessions |
EDL24724 EDL24725 Q8JZL1 AF424804 AAL79530 AF459444 AAM28441 AF494209 AAM74078 AF494210 AAM74079 AK012666 BAB28395 AK133233 BAE21569 AK139904 BC065776 AAH65776 BC066804 BC106187 AAI06188 BC138629 AAI38630 BC152929 AAI52930 BY152713 CD564540 XM_006518667 XP_006518730 XM_006518668 XP_006518731 NM_027265 NM_134437 NP_602319
|
| Function |
Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK (By similarity). Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons. {ECO:0000250, ECO:0000269|PubMed:12604616, ECO:0000269|PubMed:15277532}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation. {ECO:0000250}.
|