| Gene Symbol |
Pla2g4a
|
| Entrez Gene |
24653
|
| Alt Symbol |
Pla2c, Pla2g4, cPLA2
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
phospholipase A2, group IVA (cytosolic, calcium-dependent)
|
| Other Description |
cytosolic phospholipase A2|phospholipase A2 cytosolic|phospholipase A2 group IVA
|
| Swissprots |
P50393
|
| Accessions |
EDM09590 P50393 BC070940 AAH70940 S77829 AAB33847 U38376 AAC21591 NM_133551 NP_598235
|
| Function |
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Translocates to membrane vesicles in a calcium-dependent fashion. {ECO:0000250}.
|
| Tissue Specificity |
In brain tissue, expressed in low levels in olfactory mitral and granule cells, in hippocampal pyramidal cells and in dentate and cerebellar granule cells.
|
| Top Pathways |
Choline metabolism in cancer, Ovarian steroidogenesis, Inflammatory mediator regulation of TRP channels, Oxytocin signaling pathway, Glutamatergic synapse
|