POLR3C

Gene Symbol POLR3C
Entrez Gene 10623
Alt Symbol RPC3, RPC62
Species Human
Gene Type protein-coding
Description polymerase (RNA) III (DNA directed) polypeptide C (62kD)
Other Description DNA-directed III 62 kDa polypeptide|DNA-directed RNA polymerase III subunit C|DNA-directed RNA polymerase III subunit RPC3|RNA polymerase III 62 kDa subunit|RNA polymerase III subunit C3
Swissprots Q9Y3R6 O15317 Q9BUI4
Accessions CAB41919 EAW71434 EAW71435 EAW71436 Q9BUI4 AK223413 BAD97133 AY091463 AAM12033 BC002586 AAH02586 BC004424 AAH04424 BC053590 BE258456 BI831011 BQ932484 DA291657 DA816269 JF432112 ADZ15329 U93867 AAB63675 XM_005272927 XP_005272984 XM_005272928 XP_005272985 XM_011509078 XP_011507380 XR_921720 XR_921721 XR_921722 XR_921723 NM_001303456 NP_001290385 NM_006468 NP_006459
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB- DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. {ECO:0000269|PubMed:19609254, E
Subcellular Location Nucleus {ECO:0000250}.
Top Pathways Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

Pol III RPC62 (I-18) - sc-69534 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Pol III RPC62 (N-18) - sc-69535 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-RPC62 antibody - ab26185 from Abcam

Prices $406.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-RPC62 antibody - ab112057 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RPC62 antibody (ab112057) at 0.4 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µgLane 5 : Mouse NIH3T3 whole cell lysate at 50 µg

Anti-RPC62 antibody - ab88243 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-RPC62 antibody (ab88243) at 1 µg/ml + HeLa nuclear extract at 50 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-RPC62 antibody - ab110401 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RPC62 antibody (ab110401) at 1/500 dilutionLane 1 : Extracts from K562 cellsLane 2 : Extracts from CoLo205 cellsLane 3 : Extracts from HuvEc cellsLane 4 : Extracts from HuvEc cells with blocking peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-RPC62 antibody - ab111995 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of RPC62 by Western Blot of Immunprecipitate. An antibody to RPC62 at 1µg/ml staining RPC62 in HeLa whole cell lysate immunoprecipitated using ab111995 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 30 seconds.

Anti-RPC62 antibody [2H1] - ab131583 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2H1
All lanes : Anti-RPC62 antibody [2H1] (ab131583) at 1/2000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNA Lane 2 : HEK293T cells transfected with pCMV6-ENTRY RPC62 cDNALysates/proteins at 5 µg per lane.

Anti-POLR3C Antibody (aa202-230, AP) - LS-C216878 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3C Antibody (aa202-230, APC) - LS-C216880 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3C Antibody (aa202-230, Biotin) - LS-C216881 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3C Antibody (aa202-230, FITC) - LS-C216882 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3C Antibody (aa202-230, Azide-free, HRP) - LS-C216883 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3C Antibody (aa202-230, PE) - LS-C216884 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3C Antibody (aa200-250) - LS-C289764 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3C Antibody (aa484-534) - LS-C289766 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3C Antibody (aa201-230) - LS-C324175 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3C Antibody (C-Terminus) - LS-C117179 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
POLR3C antibody LS-C117179 Western blot of 293T cell lysate.

Anti-POLR3C Antibody (aa202-230) - LS-C158698 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of POLR3C (arrow) using rabbit polyclonal POLR3C Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the POLR3C gene.

Anti-POLR3C Antibody (clone 2H1) - LS-C174149 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2H1
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-POLR3C mouse monoclonal antibody.

RPC62 Antibody - NBP1-87110 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RPC62 Antibody [NBP1-87110] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells) Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells)

RPC62 Antibody - NBP1-87111 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RPC62 Antibody [NBP1-87111] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Negative control (vector only transfected HEK293T lysate)<br/>Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY401943)

RPC62 Antibody - H00010623-B03P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: RPC62 Antibody [H00010623-B03P] - Analysis of POLR3C expression in human placenta.

RPC62 Antibody - H00010623-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: RPC62 Antibody [H00010623-B01] - analysis of POLR3C expression in transfected 293T cell line by POLR3C MaxPab polyclonal antibody (B01). Lane 1: POLR3C transfected lysate (60.60 KDa). Lane 2: Non-transfected lysate.

RPC62 Antibody - H00010623-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
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