URI1

Gene Symbol	URI1
Entrez Gene	8725
Alt Symbol	C19orf2, NNX3, PPP1R19, RMP, URI
Species	Human
Gene Type	protein-coding
Description	URI1, prefoldin-like chaperone
Other Description	RNA polymerase II subunit 5-mediating protein|RPB5-mediating protein|protein phosphatase 1 regulatory subunit 19|protein phosphatase 1, regulatory subunit 19|unconventional prefoldin RPB5 interactor 1
Swissprots	A8K805 Q9UNU3 Q8TC23 H7BY42 O94763
Accessions	O94763 AA678820 AF091095 AAD08679 AK001437 BAG50914 AK226173 AK292170 BAF84859 AK314313 AW003989 AW954529 BC014933 AAH14933 BC026184 AAH26184 BC067259 AAH67259 BG742069 DB461036 HQ234306 XM_005259362 XP_005259419 XM_005259363 XP_005259420 XM_011527435 XP_011525737 NM_001252641 NP_001239570 NM_003796 NP_003787 NR_045557 NM_134447
Function	Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.
Subcellular Location	Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite {ECO:0000250}. Note=Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion.
Tissue Specificity	Ubiquitous. Expressed in ovarian cancers (at protein level). Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells. {ECO:0000269|PubMed:21397856, ECO:0000269|PubMed:21730289, ECO:0000269|PubMed:9819440, ECO:0000269|PubMed:9878255}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® RMP siRNA I - 6464 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® RMP siRNA II - 6495 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

RMP CRISPR/Cas9 KO Plasmid (h) - sc-406916 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RMP HDR Plasmid (h) - sc-406916-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RMP Double Nickase Plasmid (h) - sc-406916-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RMP Double Nickase Plasmid (h2) - sc-406916-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RMP CRISPR Activation Plasmid (h) - sc-406916-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RMP CRISPR Activation Plasmid (h2) - sc-406916-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RMP Lentiviral Activation Particles (h) - sc-406916-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RMP Lentiviral Activation Particles (h2) - sc-406916-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RMP siRNA (h) - sc-97138 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RMP shRNA Plasmid (h) - sc-97138-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RMP shRNA (h) Lentiviral Particles - sc-97138-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU086351 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN4520 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4520 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05904 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr05904

URI1 siRNA (Human) - CRH5745 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

URI RNAi - H00008725-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

URI RNAi - H00008725-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

URI1 - MBS8208602 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RMP CRISPR/Cas9 KO Plasmid (h2) - sc-406916-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RMP HDR Plasmid (h2) - sc-406916-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Human URI1 siRNA - orb266247 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

URI1 shRNA Plasmid (Human) - CHH5745 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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