| Gene Symbol |
Kcnj1
|
| Entrez Gene |
24521
|
| Alt Symbol |
Kcnj, ROMK1
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, inwardly rectifying subfamily J, member 1
|
| Other Description |
ATP-regulated potassium channel ROM-K|ATP-sensitive inward rectifier potassium channel 1|K+ channel protein|KAB-1|Potassium inwardly-rectifying channel subfamily J|inward rectifier K(+) channel Kir1.1|kir1.1|potassium channel, inwardly rectifying subfamily J member 1|potassium inwardly-rectifying channel, subfamily J, member 1
|
| Swissprots |
O88639 O88640 P35560 Q9QUR5
|
| Accessions |
EDL83291 EDL83292 EDL83293 EDL83294 EDL83295 EDL83296 P35560 AF081365 AAC34443 AF081366 AAC34444 AF081367 AAC34445 AF081368 AAC34446 L29403 AAA50378 X72341 CAA51068 XM_008766044 XP_008764266 XM_008766045 XP_008764267 XM_008766046 XP_008764268 XM_008766047 XP_008764269 XM_008766048 XP_008764270 NM_017023 NP_058719
|
| Function |
In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Note=Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. {ECO:0000250}.
|
| Tissue Specificity |
Mainly in kidney (renal cortex, medulla and papilla). In the brain, found in the cortex and the hippocampus.
|
| Top Pathways |
Aldosterone-regulated sodium reabsorption, Gastric acid secretion
|