ACE

Gene Symbol ACE
Entrez Gene 1636
Alt Symbol ACE1, CD143, DCP, DCP1, ICH, MVCD3
Species Human
Gene Type protein-coding
Description angiotensin I converting enzyme
Other Description CD143 antigen|angiotensin I converting enzyme (peptidyl-dipeptidase A) 1|angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript|angiotensin converting enzyme, somatic isoform|angiotensin-converting enzyme|carboxycathepsin|dipeptidyl carboxypeptidase 1|dipeptidyl carboxypeptidase I|kininase II|peptidase P|testicular ECA
Swissprots E7EU16 B0LPF0 Q59GY8 P22966 Q7M4L4 Q53YX9 P12821 B4DXI3
Accessions AAD28560 AAD28561 AAP03651 AAP13243 AAR03504 ABA39228 ABA39229 ABY87529 AHV83440 CAA02045 EAW94311 EAW94312 EAW94313 EAW94314 EAW94315 EAW94316 EAW94317 EAW94318 EAW94319 EAW94320 EAW94321 P12821 AB208971 BAD92208 AK296566 BAG59186 AK300516 BAG62228 AK301988 BAG63395 AK302019 BAG63418 AK309514 BM908180 BM908222 J04144 AAA51684 JQ927553 AFK65504 M26657 AAA60611 M29981 S81361 AAD14360 X16295 CAA34362 XM_005257110 XP_005257167 XM_006721737 XP_006721800 NM_000789 NP_000780 NM_001178057 NP_001171528 NM_152830 NP_690043 NM_152831
Function Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Subcellular Location Angiotensin-converting enzyme, soluble form: Secreted.
Tissue Specificity Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis. {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:12459472, ECO:0000269|PubMed:15671045}.
Top Pathways Hypertrophic cardiomyopathy (HCM), Chagas disease (American trypanosomiasis), Renin-angiotensin system

ACE CRISPR/Cas9 KO Plasmid (h) - sc-400759 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE HDR Plasmid (h) - sc-400759-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE Double Nickase Plasmid (h) - sc-400759-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE Double Nickase Plasmid (h2) - sc-400759-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE CRISPR Activation Plasmid (h) - sc-400759-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE CRISPR Activation Plasmid (h2) - sc-400759-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE Lentiviral Activation Particles (h) - sc-400759-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE Lentiviral Activation Particles (h2) - sc-400759-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE siRNA (h2) - sc-270350 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ACE shRNA Plasmid (h2) - sc-270350-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ACE shRNA (h2) Lentiviral Particles - sc-270350-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ACE/CD143 RNAi - H00001636-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

ACE/CD143 RNAi - H00001636-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ACE/CD143 RNAi - H00001636-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU160811 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1813 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1813 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ACE siRNA (Human) - CRH1152 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ACE - MBS8218610 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ACE CRISPR/Cas9 KO Plasmid (h2) - sc-400759-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE HDR Plasmid (h2) - sc-400759-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human ACE (NM_000789.3) - SHH230206 from Creative biogene

Category siRNA
Species Reactivities Human

Human ACE siRNA - orb261654 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ACE shRNA Plasmid (Human) - CHH1152 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ACE miRNA 3'UTR clone - MiUTR3H-00147 from Creative biogene

Species Reactivities Human
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