| Gene Symbol |
csw
|
| Entrez Gene |
45278
|
| Alt Symbol |
19-106, CG3954, CSW, Csw, Csw/Shp2, Dmel\CG3954, E(sev)1A, EG:BACN25G24.2, SHP-2, Shp-2, Shp2/csw, anon-WO03040301.207, anon-WO03040301.209, anon-WO03040301.219, csw/SHP-2, l(1)2Db, l(1)2Dd, l(1)G0170, l(1)GA114, l(1)csw
|
| Species |
Drosophila
|
| Gene Type |
protein-coding
|
| Description |
corkscrew
|
| Other Description |
CG3954-PA|CG3954-PB|CG3954-PC|CG3954-PD|csw-PA|csw-PB|csw-PC|csw-PD|enhancer of sevenless 1A
|
| Swissprots |
P29349 Q8I0H8 Q9W524 Q24033 Q8ISD6 Q8I074 Q9V3H1 Q24032 Q8I0S4 Q8ISD5
|
| Accessions |
AAF45724 AAF45725 AAG22389 AAN17610 AAN17612 AAN17614 AAN17616 AAN17618 AAN17622 AAN17624 AAN17626 AGB95020 CAB65870 CAB65871 BT001484 AAN71239 BT149891 AGD79328 M94730 AAA28433 NM_001272245 NP_001259174 NM_057782 NP_477130 NM_057783 NP_477131 NM_166928 NP_726793
|
| Function |
Required in all receptor tyrosine kinase signaling pathways. Functions downstream of the receptor tyrosine kinase torso, acting in concert with D-Raf via tailless. Also functions downstream of Egfr (epidermal growth factor receptor) and btl (fibroblast growth factor receptor). The SH2 domain suggests that csw effects its role by mediating heteromeric protein interactions. Maternally required for normal determination of cell fates at the termini of the embryo. Required for cell fate specification of the ventral ectoderm, in the developing embryonic CNS and for embryonic tracheal cell migration. Functions during imaginal development for proper formation of adult structures such as eyes, aristae, L5 wing vein and the tarsal claw. {ECO:0000269|PubMed:1638629, ECO:0000269|PubMed:8948575}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Expressed uniformly throughout all tissues during embryogenesis. {ECO:0000269|PubMed:1638629}.
|
| Top Pathways |
Jak-STAT signaling pathway, MAPK signaling pathway - fly
|