| Gene Symbol | SLC26A3 |
|---|---|
| Entrez Gene | 1811 |
| Alt Symbol | CLD, DRA |
| Species | Human |
| Gene Type | protein-coding |
| Description | solute carrier family 26 (anion exchanger), member 3 |
| Other Description | chloride anion exchanger|down-regulated in adenoma protein|solute carrier family 26, member 3 |
| Swissprots | P40879 |
| Accessions | AAB88772 EAW83418 EAW83419 EAW83420 P40879 AK300651 BAG62339 BC025671 AAH25671 BP262081 BX640837 CAE45910 DQ891550 ABM82476 EU176616 ABW03417 L02785 AAA58443 XM_011515867 XP_011514169 NM_000111 NP_000102 |
| Function | Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. |
| Subcellular Location | Apical cell membrane {ECO:0000269|PubMed:22159084}; Multi-pass membrane protein {ECO:0000269|PubMed:22159084}. Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). {ECO:0000250}. |
| Top Pathways | Pancreatic secretion, Mineral absorption |