| Gene Symbol |
TRAF5
|
| Entrez Gene |
7188
|
| Alt Symbol |
MGC:39780, RNF84
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TNF receptor-associated factor 5
|
| Other Description |
RING finger protein 84
|
| Swissprots |
Q6FHY1 B4E0A2 B4DIS9 O00463
|
| Accessions |
EAW93419 EAW93420 EAW93421 EAW93422 O00463 AB000509 BAA25262 AK126502 BAG54338 AK295766 BAG58591 AK303286 BAG64364 BC029600 AAH29600 BC032830 BM453281 BU676629 CD709275 CR536557 CAG38794 DB218840 DB290838 GQ129370 ACT64504 GQ129371 ACT64505 U69108 AAC51329 XM_011509956 XP_011508258 XM_011509957 XP_011508259 XM_011509958 XP_011508260 XM_011509959 XP_011508261 XM_011509960 XP_011508262 NM_001033910 NP_001029082 NM_004619 NP_004610 NM_145759 NP_665702
|
| Function |
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. {ECO:0000269|PubMed:15121867}.
|
| Subcellular Location |
Cytoplasm {ECO:0000305|PubMed:15121867}. Cytoplasm, cytosol {ECO:0000269|PubMed:15121867}.
|
| Tissue Specificity |
Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.
|
| Top Pathways |
Small cell lung cancer, Herpes simplex infection, Viral carcinogenesis, Epstein-Barr virus infection, TNF signaling pathway
|