RIPK3

Gene Symbol	RIPK3
Entrez Gene	11035
Alt Symbol	RIP3
Species	Human
Gene Type	protein-coding
Description	receptor-interacting serine-threonine kinase 3
Other Description	RIP-3|RIP-like protein kinase 3|receptor interacting protein 3|receptor-interacting protein 3|receptor-interacting serine/threonine-protein kinase 3
Swissprots	C4AM87 Q5J795 B4DJL9 Q5J796 Q9Y572 Q6P5Y1
Accessions	EAW66021 EAW66022 Q9Y572 AF156884 AAD39005 AK075275 AK296140 BAG58881 AK296309 BAG59007 AY453693 AAS16359 AY494982 AAS75516 AY494983 AAS75517 BC041668 BC062584 AAH62584 BE676675 DB274842 NM_006871 NP_006862
Function	Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. {ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:22265413}. Cell membrane {ECO:0000250}. Mitochondrion {ECO:0000305}.
Tissue Specificity	Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers. {ECO:0000269|PubMed:15896315}.
Top Pathways	Cytosolic DNA-sensing pathway, TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Receptor interacting protein 3 Gene - orb145066 from Biorbyt Prices $366.00 Sizes 10 μg Species Human

RIPK3 - MBS1269211 from MyBioSource Prices $250.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC041668

Human RIPK3 ORF Clone(NM_006871.3) - CDCR293870 from Creative Biomart Species Human Accession NM_006871.3

Human RIPK3 ORF Clone(NM_006871.3) - CDCR293871 from Creative Biomart Species Human Accession NM_006871.3

Human RIPK3 ORF Clone(NM_006871.3) - CDCR293872 from Creative Biomart Species Human Accession NM_006871.3

Human RIPK3 ORF clone(NM_006871.3) - CDCL185983 from Creative Biomart Species Human Accession NM_006871.3

Human RIPK3 Gene ORF cDNA clone in cloning vector - HG11267-G from Sino Biological Species Human

Human RIPK3 Gene ORF cDNA clone expression plasmid, C-His tag - HG11267-CH from Sino Biological Species Human

Human RIPK3 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11267-ANG from Sino Biological Species Human

Human RIPK3 Gene ORF cDNA clone expression plasmid, N-His tag - HG11267-NH from Sino Biological Species Human

Human RIPK3 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11267-CY from Sino Biological Species Human

Human RIPK3 Gene ORF cDNA clone expression plasmid - HG11267-UT from Sino Biological Species Human

Human RIPK3 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11267-ACR from Sino Biological Species Human

Human RIPK3 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11267-ANR from Sino Biological Species Human

Human RIPK3 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11267-ACG from Sino Biological Species Human

Human RIPK3 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11267-NF from Sino Biological Species Human

Human RIPK3 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11267-NM from Sino Biological Species Human

Human RIPK3 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11267-CF from Sino Biological Species Human

Human RIPK3 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11267-CM from Sino Biological Species Human

Human RIPK3 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11267-NY from Sino Biological Species Human

Human RIPK3 ORF clone(NM_006871.3) - CDCL185983 from Creative biogene Species Human

Human RIPK3 ORF Clone (BC041668) - CDCS412962 from Creative biogene Species Human Accession Q9Y572

Human RIPK3/RIP3 (NP_006862) VersaClone cDNA - RDC2118 from R&D Systems Prices $199.00 Sizes 10 µg Species Human

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