| Gene Symbol |
E2F5
|
| Entrez Gene |
1875
|
| Alt Symbol |
E2F-5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
E2F transcription factor 5, p130-binding
|
| Other Description |
transcription factor E2F5
|
| Swissprots |
Q16601 Q15329 Q92756 E9PBN9
|
| Accessions |
AAN46737 CBJ05776 CBJ21228 EAW87122 EAW87123 Q15329 AB209185 BAD92422 AI740797 BC156210 AAI56211 BC172475 AAI72475 BM919591 BP224536 CN312917 DB534924 U15642 AAC50120 U31556 AAB00179 X86097 CAA60051 Z78409 CAB01634 XM_006716434 XP_006716497 XM_011517477 XP_011515779 NM_001083588 NP_001077057 NM_001083589 NP_001077058 NM_001951 NP_001942
|
| Function |
Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor- initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
Cell cycle, TGF-beta signaling pathway
|