TUP1

Gene Symbol TUP1
Entrez Gene 850445
Alt Symbol AAR1, AER2, AMM1, CRT4, CYC9, FLK1, ROX4, SFL2, UMR7
Species Yeast
Gene Type protein-coding
Description chromatin-silencing transcriptional regulator TUP1
Other Description -
Swissprots P17995 P18323 D6VR85 P16649
Accessions DAA07554 P16649 NM_001178790 NP_010007
Function Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex. {ECO:0000269|PubMed:10722672, ECO:0000269|PubMed:11069890, ECO:0000269|PubMed:11172717, ECO:0000269|PubMed:11230135, ECO:0000269|PubMed:11784848, ECO:0000269|PubMed:14665463, ECO:0000269|PubMed:2247069}.
Subcellular Location Nucleus {ECO:0000269|PubMed:14562095}.
Top Pathways Cell cycle - yeast

General transcriptional corepressor TUP1 (TUP1), partial, Recombinant Protein - MBS1211758 from MyBioSource

Category Protein
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Yeast
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