HSD11B1

Gene Symbol	HSD11B1
Entrez Gene	3290
Alt Symbol	11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1
Species	Human
Gene Type	protein-coding
Description	hydroxysteroid (11-beta) dehydrogenase 1
Other Description	corticosteroid 11-beta-dehydrogenase isozyme 1|short chain dehydrogenase/reductase family 26C member 1|short chain dehydrogenase/reductase family 26C, member 1
Swissprots	P28845 D3DT89 B2R9Z1
Accessions	AAC31757 AAK83653 EAW93445 EAW93446 P28845 AK313973 BAG36688 BC012593 AAH12593 BG619051 BM994393 BX345837 CB530075 CF596989 CF597174 DQ892912 ABM83838 EU176721 ABW03522 KJ534869 AHW56509 NM_001206741 NP_001193670 NM_005525 NP_005516 NM_181755 NP_861420
Function	Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity). {ECO:0000250}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:10497248}; Single-pass type II membrane protein {ECO:0000269|PubMed:10497248}.
Tissue Specificity	Widely expressed. Highest expression in liver.
Top Pathways	Steroid hormone biosynthesis, Chemical carcinogenesis, Metabolism of xenobiotics by cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HSD11B1 peptide - ab101097 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

HSD11B1 peptide (281-291) - ab45666 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human HDL full length protein - ab77897 from Abcam Category Protein Source Native Species Human

Human HDL full length protein - ab77881 from Abcam Category Protein Source Native Species Human

Human HDL full length protein - ab80476 from Abcam Category Protein Source Native Species Human

Human HSD11B1 full length protein - ab114301 from Abcam Category Protein Source Wheat germ Species Human

Human HSD11B1 peptide - ab99223 from Abcam Category Peptide Species Human

Human HSD11B1 peptide - ab101308 from Abcam Category Peptide

HSD11B1 / HSD11B Antibody Blocking Peptide - LS-E25809 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HSD11B1 / HSD11B Antibody Blocking Peptide - LS-E27741 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human 11 beta-HSD1 Protein - H00003290-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

HDL Native Protein - NBP1-99178 from Novus Biologicals Category Protein Prices $98.00 Sizes 1 mg Source Human Species Human

HSD11B1 blocking peptide - GTX89627-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Bovine

HDL Protein (OPPA01436) - OPPA01436 from Aviva Systems Biology Category Protein Prices $180.00 Sizes 10 mg

Human HSD11B1 protein - orb244279 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human HDL protein - orb81154 from Biorbyt Category Protein Prices $289.00, $595.00 Sizes 10 mg, 100 mg Species Human

Hsd11b1 Immunizing peptide - orb66268 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

HDL protein - 30-AH08 from Fitzgerald Category Protein Prices $104.50 Sizes 1 mg

HDL protein - 30-1133 from Fitzgerald Category Protein Prices $105.00 Sizes 10 mg Species Human

HDL protein - 30R-2779 from Fitzgerald Category Protein Prices $175.00 Sizes 1 mg Species Human

HSD11B1 Blocking Peptide - 33R-7614 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HSD11B1 Blocking Peptide - abx062746 from Abbexa Category Peptide Species Human, Rat, Dog, Rabbit

HSD11B1 Peptide - AC21-0640-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

11-beta HSD1 / HSD11B1 - H00003290-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

11-beta HSD1 / HSD11B1 - H00003290-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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