| Gene Symbol |
Slc17a6
|
| Entrez Gene |
84487
|
| Alt Symbol |
Dnpi, Vglut2
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 17 (vesicular glutamate transporter), member 6
|
| Other Description |
differentation-associated Na-dependent inorganic phosphate cotransporter|differentiation-associated BNPI|differentiation-associated Na(+)-dependent inorganic phosphate cotransporter|solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6|solute carrier family 17 member 6|vesicular glutamate transporter 2
|
| Swissprots |
Q9JI12
|
| Accessions |
EDM07210 Q9JI12 AF271235 AAF76223 FQ211915 XM_006229265 XP_006229327 NM_053427 NP_445879
|
| Function |
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas. May also mediate the transport of inorganic phosphate. {ECO:0000269|PubMed:11502256, ECO:0000269|PubMed:11551935, ECO:0000269|PubMed:11698619, ECO:0000269|PubMed:11698620, ECO:0000269|PubMed:17046815, ECO:0000269|PubMed:18080752}.
|
| Subcellular Location |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome.
|
| Tissue Specificity |
Expressed in brain (at protein level). Expressed in brainstem, deep nuclei, septal nuclei, nuclei of the diagonal band, frontal cortex, hypothalamus, midbrain, parietal cortex and temporal cortex. Also expressed in pineal gland and islets of Langerhans. {ECO:0000269|PubMed:11502256, ECO:0000269|PubMed:11551935, ECO:0000269|PubMed:11698619, ECO:0000269|PubMed:11698620}.
|
| Top Pathways |
Synaptic vesicle cycle, Glutamatergic synapse, Nicotine addiction, Retrograde endocannabinoid signaling
|