| Gene Symbol |
NARFL
|
| Entrez Gene |
64428
|
| Alt Symbol |
HPRN, IOP1, LET1L, PRN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear prelamin A recognition factor-like
|
| Other Description |
LET1 like/JFP15|cytosolic Fe-S cluster assembly factor NARFL|iron-only hydrogenase-like protein 1|protein related to Narf
|
| Swissprots |
Q9H6Q4 A1L385 Q9H6J8 Q53GC6 Q96S10 B3KTJ3
|
| Accessions |
AAK61251 EAW85722 EAW85723 EAW85724 Q9H6Q4 AK025641 BAB15199 AK025861 BAB15261 AK056467 BAG51721 AK094812 AK095675 BAG53105 AK126151 AK223005 BAD96725 AK293591 BAG57058 AK300087 BAG61890 AK301023 BAG62639 AK310875 AY129231 AAM98737 BC030248 AAH30248 BC129940 AAI29941 BU741568 DA153375 DB126434 NM_001304799 NP_001291728 NM_022493 NP_071938
|
| Function |
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. {ECO:0000269|PubMed:16956324, ECO:0000269|PubMed:18270200}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:16956324}.
|
![Western Blot: NARFL Overexpression Lysate (Adult Normal) [NBL1-13480] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NARFL.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4597_NARFL%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13480-img0002.jpg)