NR1H3

Gene Symbol NR1H3
Entrez Gene 10062
Alt Symbol LXR-a, LXRA, RLD-1
Species Human
Gene Type protein-coding
Description nuclear receptor subfamily 1, group H, member 3
Other Description liver X nuclear receptor alpha variant 1|oxysterols receptor LXR-alpha
Swissprots Q96H87 Q8IW13 D3DQR1 Q13133 A8K3J9
Accessions EAW67942 EAW67943 EAW67944 EAW67945 EAW67946 EAW67947 EAW67948 EAW67949 Q13133 AA644385 AB307698 BAH02289 AI097478 AI648486 AK122661 BAG53649 AK290614 BAF83303 AK302132 BAG63507 AK309027 AK311590 AK313311 BAG36116 AU133574 AU135617 BC008819 AAH08819 BC041172 AAH41172 BM835230 BP300071 BT019411 AAV38218 CV026805 EU831967 ACE87408 EU832060 ACE86722 HQ692819 ADZ17330 U22662 AAA85856 XM_005252705 XP_005252762 XM_005252706 XP_005252763 XM_005252707 XP_005252764 XM_005252709 XP_005252766 XM_005252710 XP_005252767 XM_005252713 XP_005252770 XM_005252715 XP_005252772 XM_005252716 XP_005252773 XM_005252718 XP_005252775 XM_006718112 XP_006718175 XM_006718113 XP_006718176 XM_006718114 XP_006718177 XM_006718115 XP_006718178 XM_006718116 XP_006718179 XM_011519805 XP_011518107 XM_011519806 XP_011518108 XM_011519807 XP_011518109 XM_011519808 XP_011518110 NM_001130101 NP_001123573 NM_001130102 NP_001123574 NM_001251934 NP_001238863 NM_001251935 NP_001238864 NM_005693 NP_005684
Function Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
Tissue Specificity Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.
Top Pathways PPAR signaling pathway, Hepatitis C, Non-alcoholic fatty liver disease (NAFLD)

LXRα (P-20) - sc-1202 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LXRα (P-20): sc-1202. Western blot analysis of LXRα expression in K-562 (A) and JAR (B) whole cell lysates.

LXRα (L-17) - sc-34386 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LXRα/β (G-10) - sc-271064 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LXRα/β (G-10): sc-271064. Western blot analysis of LXRβ expression in non-transfected: sc-117752 (A) and human LXRβ transfected: sc-116107 (B) 293T whole cell lysates.

LXRα/β (H-7) - sc-377260 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LXRα/β (H-7): sc-377260. Western blot analysis of LXRβ expression in non-transfected: sc-117752 (A) and human LXRβ transfected: sc-112157 (B) 293T whole cell lysates.

Anti-LXR alpha + LXR beta antibody - ab24532 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LXR alpha antibody - ab28478 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-LXR alpha antibody (ab28478) (at a dilution of 1/500) + mouse liver samples

Anti-LXR alpha antibody - ab106464 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of LXR alpha in rat liver tissue with ab106464 at 20 ug/mL.

Anti-LXR alpha antibody - ab135039 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-LXR alpha antibody (ab135039) at 1/1000 dilution + Mouse liver total cell extracts

Anti-LXR alpha antibody - ab103356 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-LXR alpha antibody (ab103356) at 1/100 dilution + MCF7 cell lysate at 35 µg

Anti-LXR alpha antibody [EPR6508(N)] - ab176323 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6508(N)
All lanes : Anti-LXR alpha antibody [EPR6508(N)] (ab176323) at 1/1000 dilutionLane 1 : Human fetal liver lysateLane 2 : Jurkat cell lysateLane 3 : MCF7 cell lysateLysates/proteins at 10 µg per lane.

Anti-LXR alpha antibody [PPZ0412] - ChIP Grade - ab41902 from Abcam

Prices $403.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone PPZ0412
ab41902 staining LXR alpha in Rat Hepatocyte and Kupffer cell paraffin section (20-40ug/mL) by Immunohistochemistry, formalin-fixed paraffin embedded sections.

Anti-NR1H3 / LXR Alpha Antibody - LS-C48584 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of NR1H3 / LXR Alpha antibody LS-C48584.

Anti-NR1H3 / LXR Alpha Antibody (aa69-329, clone 1F5) - LS-C339445 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F5
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NR1H3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NR1H3.

Anti-NR1H3 / LXR Alpha Antibody (clone NR1HB11D6) - LS-C342354 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone NR1HB11D6
Left : Western blot analysis of immunized recombinant protein, using anti-NR1H3 monoclonal antibody. Right : CBB staining of immunized recombinant protein.

Anti-NR1H3 / LXR Alpha Antibody (clone 3E9) - LS-C139252 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3E9
Western blot of NR1H3 expression in transfected 293T cell line by NR1H3 monoclonal antibody LS-C139252

Anti-NR1H3 / LXR Alpha Antibody - LS-C192954 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts of MCF7 cell lines, using NR1H3 antibody.

Anti-NR1H3 / LXR Alpha Antibody - LS-C331934 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of HT29 cell lines, using NR1H3 antibody.

Anti-NR1H3 / LXR Alpha Antibody (aa371-385) - LS-C343870 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
NR1H3 antibody Western blot. All lanes: Anti NR1H3 at 0.5 ug/ml. Lane 1: Rat Liver Tissue Lysate at 50 ug. Lane 2: Rat Lung Tissue Lysate at 50 ug. Lane 3: Rat Spleen Tissue Lysate at 50 ug. Lane 4: Rat Kidney Tissue Lysate at 50 ug. Lane 5: Human Placenta Tissue Lysate at 50 ug. Predicted band size: 51 kD. Observed band size: 51 kD.

Anti-NR1H3 / LXR Alpha Antibody (aa226-253) - LS-C162986 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Fluorescent image of U251 cell stained with NR1H3 Antibody. U251 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with NR1H3 primary antibody (1:25, 1 h at 37°C). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37°C). Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37°C). NR1H3 immunoreactivity is localized to Nucleus significantly.

Anti-NR1H3 / LXR Alpha Antibody (N-Terminus) IHC-plus™ - LS-B4626 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NR1H3 / LXR Alpha antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4626 concentration 5 ug/ml.

Anti-NR1H3 / LXR Alpha Antibody (C-Terminus) IHC-plus™ - LS-B3526 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NR1H3 / LXR Alpha antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3526 concentration 5 ug/ml.

Anti-NR1H3 / LXR Alpha Antibody (aa164-447) - LS-C9359 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-NR1H3 / LXR Alpha Antibody - LS-C37815 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-NR1H3 / LXR Alpha Antibody (N-Terminus) - LS-C31064 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: Jurkat Cell Lysate

Anti-NR1H3 / LXR Alpha Antibody (Internal) - LS-C131111 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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