ABI1

Gene Symbol ABI1
Entrez Gene 10006
Alt Symbol ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1
Species Human
Gene Type protein-coding
Description abl-interactor 1
Other Description Abelson interactor 1|Abl-interactor protein 1 long|abl interactor 1|abl-binding protein 4|eps8 SH3 domain-binding protein|interactor protein AblBP4|nap1 binding protein|spectrin SH3 domain-binding protein 1
Swissprots Q96S81 Q9NYB8 B4DQ58 Q8TB63 A9Z1Y6 H7BXI6 Q9NXZ9 Q8IZP0 O76049 O95060 Q5T2R3 Q5W072 Q5T2R7 B3KX62 Q5T2R6 Q5T2R9 O15147 Q5W070 Q5T2R4
Accessions CAB88006 CCQ43032 EAW86077 EAW86078 EAW86079 EAW86080 EAW86081 EAW86082 EAW86083 Q8IZP0 AB040151 BAB55675 AB209268 BAD92505 AF001628 AAD00897 AF006516 AAB62569 AF260262 AAF70309 AF540955 AAN28379 AK126803 BAG54374 AK291823 BAF84512 AK296751 BAG59334 AK298646 BAG60820 AK315914 BAH14285 BC013238 BC024254 AAH24254 DB019974 FJ380057 ACJ12783 FJ380058 ACJ12784 FJ380059 ACJ12785 U87166 AAC39757 XM_005252332 XP_005252389 XM_005252333 XP_005252390 XM_006717359 XP_006717422 XM_006717360 XP_006717423 XM_006717361 XP_006717424 XM_011519289 XP_011517591 NM_001012750 NP_001012768 NM_001012751 NP_001012769 NM_001012752 NP_001012770 NM_001178116 NP_001171587 NM_001178119 NP_001171590 NM_001178120 NP_001171591 NM_001178121 NP_001171592 NM_001178122 NP_001171593 NM_001178123 NP_001171594 NM_001178124 NP_001171595 NM_001178125 NP_001171596 NM_005470 NP_005461
Function May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity). {ECO:0000250}.
Tissue Specificity Widely expressed, with highest expression in brain. {ECO:0000269|PubMed:11418237}.

Abi-1 (B-12) - sc-271180 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Abi-1 (B-12): sc-271180. Western blot analysis of Abi-1 expression in HeLa whole cell lysate.

Abi-1 (C-1) - sc-398554 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Abi-1 (C-1): sc-398554. Western blot analysis of Abi-1 expression in non-transfected 293T: sc-117752 (A), mouse Abi-1 transfected 293T: sc-126367 (B), HeLa (C), Jurkat (D) and MCF7 (E) whole cell lysates.

Abi-1 (T-15) - sc-20323 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Abi-1 (T-15): sc-20323. Western blot analysis of Abi-1 expression in non-transfected: sc-117752 (A) and mouse Abi-1 transfected: sc-126367 (B) 293T whole cell lysates.

Abi-1 (H-80) - sc-30038 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Abi-1 (H-80): sc-30038. Western blot analysis of Abi-1 expression in non-transfected: sc-117752 (A) and mouse Abi-1 transfected: sc-126367 (B) 293T whole cell lysates.

Abi-2 (B-3) - sc-393982 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Abi-2 (B-3): sc-393982. Western blot analysis of Abi-2 expression in non-transfected: sc-117752 (A) and human Abi-2 transfected: sc-176387 (B) 293T whole cell lysates.

Anti-SSH3BP1 (phospho Y435) antibody - ab55834 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SSH3BP1 (phospho Y435) antibody [EP3954] - ab109395 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP3954
All lanes : Anti-SSH3BP1 (phospho Y435) antibody [EP3954] (ab109395) at 1/10000 dilutionLane 1 : Jurkat cell lysate, untreatedLane 2 : Jurkat cell lysate, treated with pervanadateLysates/proteins at 10 µg per lane.

Anti-SSH3BP1 antibody - ab72318 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma tissue labelling SSH3BP1 with ab72318 at 1/200 (1µg/ml). Detection: DAB.

Anti-SSH3BP1 antibody - ab62660 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SSH3BP1 antibody - ab91251 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SSH3BP1 antibody (ab91251) at 1/100 dilution + MCF7 cell line lysate at 35 µg

Anti-SSH3BP1 antibody - ab111212 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SSH3BP1 antibody - ab75264 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
1/250 ab75264 staining formalin-fixed, paraffin-embedded human ovarian carcinoma tissue. Detection: DAB staining.

Anti-SSH3BP1 antibody - ab72317 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SSH3BP1 antibody [4E2] - ab11222 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4E2
IHC image of ab11222 staining in human normal skin formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab11222, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-SSH3BP1 antibody - Carboxyterminal end - ab65828 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SSH3BP1 antibody - Carboxyterminal end - ab55901 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SSH3BP1 antibody - N-terminal - ab199915 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-SSH3BP1 antibody - N-terminal (ab199915) at 1/1000 dilutionLane 1 : Total cell extract from mouse brainLane 2 : Total cell extract from mouse thymus

Anti-ABI1 / ABI-1 Antibody - LS-C39206 from LifeSpan Bioscience

Prices $965.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-ABI1 / SSH3BP1 Antibody (phospho-Tyr435) - LS-C47095 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ABI1 / SSH3BP1 Antibody (C-Terminus) - LS-C47047 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ABI1 / ABI-1 Antibody (aa325-375) - LS-C63404 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-ABI1 / ABI-1 Antibody (aa150-200) - LS-C63399 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ABI1 / SSH3BP1 Antibody (C-Terminus) - LS-C121182 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ABI1 / SSH3BP1 Antibody (C-Terminus) - LS-C145162 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ABI1 / SSH3BP1 Antibody (C-Terminus, Magnetic beads) - LS-C171632 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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