IGF1

Gene Symbol IGF1
Entrez Gene 3479
Alt Symbol IGF-I, IGF1A, IGFI
Species Human
Gene Type protein-coding
Description insulin-like growth factor 1 (somatomedin C)
Other Description IGF-IA|IGF-IB|MGF|insulin-like growth factor I|insulin-like growth factor IA|insulin-like growth factor IB|mechano growth factor|somatomedin-C
Swissprots Q14620 P01343 B2RWM7 P05019 E9PD02
Accessions AAA52537 AAA52538 AAA52788 AAA52790 AAB21519 AAO74829 AAV40833 CAA27152 CAA27153 CAA27154 CAA27250 CAY39134 EAW97695 EAW97696 EAW97697 EAW97698 P05019 AB209184 BAD92421 AK312231 BAG35164 BC148266 AAI48267 BC152321 AAI52322 BC160082 AAI60082 CR541861 CAG46659 M11568 AAA52539 M27544 AAA52787 M29644 AAA52543 M37484 AAA52789 U40870 AAA96152 X00173 CAA24998 X56773 CAA40092 X56774 CAA40093 X57025 CAA40342 XR_944534 XR_944535 XR_944536 NM_000618 NP_000609 NM_001111283 NP_001104753 NM_001111284 NP_001104754 NM_001111285 NP_001104755
Function The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. {ECO:0000269|PubMed:21076856, ECO:0000269|PubMed:24132240}.
Subcellular Location Secreted.
Top Pathways Focal adhesion, Rap1 signaling pathway, Long-term depression, Proteoglycans in cancer, Signaling pathways regulating pluripotency of stem cells

IGF-I (C-20) - sc-7144 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IGF-I (C-20): sc-7144. Western blot analysis of human recombinant IGF-I fusion protein.

IGF-I (G-17) - sc-1422 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IGF-I (G-17): sc-1422. Western blot analysis of human recombinant IGF-I.

IGF-I (H-70) - sc-9013 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IGF-I (H-70): sc-9013. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes.

IGF-I (W18) - sc-74116 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
IGF-I (W18): sc-74116. Western blot analysis of human recombinant IGF-I fusion protein.

Anti-IGF1 antibody - ab9572 from Abcam

Prices $398.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab9572 staining Human normal liver parenchyma. Staining is localised to the cytoplasm.Left panel: with primary antibody at 4 ug/ml. Right panel: isotype control.Sections were stained using an automated system DAKO Autostainer Plus , at room temperature: sections were rehydrated and antigen retrieved with the Dako 3 in 1 AR buffer EDTA pH 9.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 mins. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 min and detected with Dako envision flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.

Anti-IGF1 antibody - ab40657 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab40657 staining IGF1 in murine prostate tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).Tissue was fixed with paraformaldehyde and an antigen retrieval step was performed using citrate buffer. Samples were then blocked with 1% serum for 20 minutes at 25°C and then incubated with ab40657 at a 1/1000 dilution for 18 hours at 4°C. The secondary used was a biotin conjugated horse polyclonal used at a 1/50 dilution.See Abreview

Anti-IGF1 antibody - ab116451 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-IGF1 antibody (ab116451) at 1/100 dilution + A549 cell line lysates at 35 µg

Anti-IGF1 antibody [1F6-3H10] - ab40789 from Abcam

Prices $372.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 1F6-3H10

Anti-IGF1 antibody [7973] - ab176523 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7973
Immunohistochemical analysis of Formalin Fixed Parafin-embedded normal Human kidney tissue labeling IGF1 with ab176523 at 1ug/ml.

Anti-IGF1 antibody [7973] (HRP) - ab187926 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 7973

Anti-IGF1 antibody (Biotin) - ab83137 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-IGF1 antibody [EPR5098(2)] - ab133542 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5098(2)
Anti-IGF1 antibody [EPR5098(2)] (ab133542) at 1/1000 dilution + Full-length IGF1 recombinant protein at 0.005 µg

Anti-IGF1 antibody [EPR5099] - ab134140 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5099
Anti-IGF1 antibody [EPR5099] (ab134140) at 1/20000 dilution (purified) + Human IGF-1 recombinant protein at 10 µgSecondaryHRP goat anti-rabbit (H+L) at 1/1000 dilution

Anti-IGF1 antibody [M23] - ab80546 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone M23
Anti-IGF1 antibody [M23] (ab80546) at 2 µg/ml + IGF1 recombinant protein

Anti-IGF1 Antibody - LS-C153240 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IGF1 Antibody - LS-C48786 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of IGF-I / IGF1 antibody LS-C48786.

Anti-IGF1 Antibody (aa80-96, Magnetic beads) - LS-C172274 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IGF1 Antibody (aa80-96, Sepharose) - LS-C172275 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IGF1 Antibody (aa80-96) - LS-C172273 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IGF1 Antibody - LS-C183441 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IGF-I / IGF1 Antibody (Internal, clone EPR5099) - LS-C138496 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5099
Western blot analysis on IGF-1 recombinant protein (5ng) using anti-IGF-1 antibody.

Anti-IGF1 Antibody - LS-C190942 from LifeSpan Bioscience

Prices $740.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-IGF1 Antibody (Biotin) - LS-C190368 from LifeSpan Bioscience

Prices $575.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-IGF1 Antibody (aa24-41) - LS-C190943 from LifeSpan Bioscience

Prices $405.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-IGF1 Antibody - LS-C147094 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of IGF-I / IGF1 antibody LS-C147094.
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