| Gene Symbol |
Numb
|
| Entrez Gene |
18222
|
| Alt Symbol |
Nb
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
numb gene homolog (Drosophila)
|
| Other Description |
protein numb homolog
|
| Swissprots |
Q9QZS3 Q9QZR1 Q9DC57 P70422 Q9QZS4 Q8CIB1
|
| Accessions |
EDL02747 EDL02748 EDL02749 EDL02750 EDL02751 EDL02752 Q9QZS3 AF169191 AAD47834 AF169192 AAD47835 AF170709 AAD47836 AK004553 BAB23367 AK085841 AK164313 AK169548 BC033459 AAH33459 BC050108 AAH50108 BY129388 U70674 AAB09586 XM_006515572 XP_006515635 XM_006515573 XP_006515636 XM_006515574 XP_006515637 XM_006515575 XP_006515638 XM_006515576 XP_006515639 XM_006515577 XP_006515640 XM_006515578 XP_006515641 XM_011244012 XP_011242314 NM_001136075 NP_001129547 NM_001272055 NP_001258984 NM_001272056 NP_001258985 NM_010949 NP_035079 NR_073563 NR_073564
|
| Function |
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. {ECO:0000269|PubMed:10841580, ECO:0000269|PubMed:12410312, ECO:0000269|PubMed:15273690, ECO:0000269|PubMed:17174898}.
|
| Subcellular Location |
Membrane; Peripheral membrane protein.
|
| Tissue Specificity |
Expressed in subventricular zone (SVZ) neuroprogenitors and ependymal cells. {ECO:0000269|PubMed:17174898}.
|
| Top Pathways |
Notch signaling pathway
|