| Gene Symbol |
Hist1h2ba
|
| Entrez Gene |
24829
|
| Alt Symbol |
Th2b
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
histone cluster 1, H2ba
|
| Other Description |
histone 1, H2ba|histone H2B type 1-A|histone H2B, testis|testis-specific histone 2b|testis-specific histone H2B
|
| Swissprots |
Q64677 Q00729
|
| Accessions |
CAA42587 Q00729 M18045 AAA74755 M18046 AAA74756 NM_022643 NP_072169
|
| Function |
Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization. Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modi
|
| Subcellular Location |
Nucleus. Chromosome.
|
| Tissue Specificity |
Testis. Expressed in pachytene spermatocytes during meiotic prophase I in the absence of any significant DNA synthesis. {ECO:0000269|PubMed:2725487}.
|
| Top Pathways |
Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism
|