BTK

Gene Symbol	BTK
Entrez Gene	695
Alt Symbol	AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA
Species	Human
Gene Type	protein-coding
Description	Bruton agammaglobulinemia tyrosine kinase
Other Description	B-cell progenitor kinase|agammaglobulinaemia tyrosine kinase|dominant-negative kinase-deficient Brutons tyrosine kinase|truncated Bruton agammaglobulinemia tyrosine kinase|tyrosine-protein kinase BTK|tyrosine-protein kinase BTK isoform (lacking exon 14)
Swissprots	B2RAW1 Q32ML5 Q06187
Accessions	AAA61479 AAB60639 AAB64205 AAC51347 AAZ38824 EAX02856 EAX02857 EAX02858 Q06187 AF153364 AAF61477 AF153755 AAF37332 AF153756 AAF37333 AF153757 AAF37334 AF153758 AAF37335 AF153759 AAF37336 AF153760 AAF37337 AF153761 AAF37338 AF153762 AAF37339 AF153763 AAF37340 AF153764 AAF37341 AJ888376 CAI59842 AJ888377 CAI59836 AJ888378 CAI59837 AJ888379 CAI59838 AJ888380 CAI59839 AJ888381 CAI59840 AK057105 BAG51864 AK225577 AK309851 AK314382 BAG37008 AM051275 CAJ19681 AM051276 CAJ19682 AM051277 CAJ19683 AM051278 CAJ19684 AM051279 CAJ19685 AM051280 CAJ19686 AM051281 CAJ19687 AM051282 CAJ19688 AM051283 CAJ19689 AM051284 CAJ19690 AM051285 CAJ19691 AM051286 CAJ19692 AU107296 AV733045 BC109079 AAI09080 BC109080 AAI09081 DA619542 DB331677 DB636737 KF241986 AGW32074 X58957 CAA41728 NM_000061 NP_000052 NM_001287344 NP_001274273 NM_001287345 NP_001274274
Function	Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. E
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1.
Tissue Specificity	Predominantly expressed in B-lymphocytes.
Top Pathways	B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Primary immunodeficiency, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human BTK full length protein - ab42616 from Abcam Category Protein Prices $321.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human BTK full length protein - ab152245 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human BTK peptide - ab39736 from Abcam Category Peptide Prices $181.00 Sizes 50 µg Species Human

BTK Antibody Blocking Peptide - LS-E2511 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BTK Antibody Blocking Peptide - LS-E30092 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

BTK Antibody Blocking Peptide - LS-E9207 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BTK [p Tyr223] Blocking Peptide - NBP1-78295PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Recombinant Human BTK Protein - H00000695-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

BTK Partial Recombinant Protein - H00000695-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

BTK Recombinant Protein - P3843 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

BTK Blocking Peptide - NBP1-76596PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

BTK Peptide - P2744 from Novus Biologicals Category Peptide Species Human

BTK-Antibody-N-term-Blocking-peptide - BP13546a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BTK-Antibody-Center-Blocking-Peptide - BP7699c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ABCA6 blocking peptide - GTX88631-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Human Btk protein - orb245766 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human BTK protein (His Tag) - orb138277 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

BTK peptide - orb219016 from Biorbyt Category Peptide Prices $357.00, $723.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey, Dog

AT peptide - orb72356 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

GATM protein (His tag) - 80R-2182 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

BTK (phospho-Tyr223) Blocking Peptide - abx062046 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine

BTK (phospho-Tyr551) Blocking Peptide - abx062047 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Dog, Monkey

Human Btk Protein - abx065610 from Abbexa Category Protein Source E.coli Species Human

BTK - H00000695-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

BTK - H00000695-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

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