CDC34

Gene Symbol	CDC34
Entrez Gene	997
Alt Symbol	E2-CDC34, UBC3, UBCH3, UBE2R1
Species	Human
Gene Type	protein-coding
Description	cell division cycle 34
Other Description	cell division cycle 34 homolog|ubiquitin carrier protein|ubiquitin-conjugating enzyme E2 R1|ubiquitin-conjugating enzyme E2-32 KDA complementing|ubiquitin-conjugating enzyme E2-CDC34|ubiquitin-protein ligase R1
Swissprots	P49427 A8K689
Accessions	AAT46688 EAW61190 EAW61191 P49427 AK291554 BAF84243 BC002332 BC009850 AAH09850 BC018143 AAH18143 BC023979 AAH23979 BT006659 AAP35305 DQ890738 ABM81664 DQ893910 ABM84836 DQ894652 ABM85578 L22005 AAC37534 XM_005259690 XP_005259747 XM_006722952 XP_006723015 NM_004359 NP_004350
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5- mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of
Subcellular Location	Cytoplasm. Nucleus. Note=The phosphorylation of the C-terminal tail plays an important role in mediating nuclear localization. Colocalizes with beta-tubulin on mitotic spindles in anaphase.
Tissue Specificity	Expressed in testes during spermatogenesis to regulate repression of cAMP-induced transcription. {ECO:0000269|PubMed:10373550}.
Top Pathways	Ubiquitin mediated proteolysis, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cell division cycle 34 Gene - orb91965 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-CDC34-cDNA-Clone - DC02795 from Abgent, a WuXi AppTec company Prices $318.60 Sizes 10 µg Species Human Accession BC009850

CDC34 - MBS1268107 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC009850

Human CDC34 Gene cDNA clone plasmid - HG11443-M from Sino Biological Species Human

Human CDC34 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11443-ANR from Sino Biological Species Human

Human CDC34 Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-tagged - HG11443-NY from Sino Biological Species Human Accession NM_004359.1

Human CDC34 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11443-CY from Sino Biological Species Human

Human CDC34 Gene ORF cDNA clone expression plasmid - HG11443-UT from Sino Biological Species Human

Human CDC34 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11443-ACG from Sino Biological Species Human

Human CDC34 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11443-ANG from Sino Biological Species Human

Human CDC34 Gene ORF cDNA clone expression plasmid, C-His tag - HG11443-CH from Sino Biological Species Human

Human CDC34 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11443-NF from Sino Biological Species Human

Human CDC34 Gene ORF cDNA clone expression plasmid, N-His tag - HG11443-NH from Sino Biological Species Human

Human CDC34 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG11443-M-N from Sino Biological Species Human Accession NM_004359.1

Human CDC34 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11443-NM from Sino Biological Species Human

Human CDC34 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11443-CF from Sino Biological Species Human

Human CDC34 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11443-CM from Sino Biological Species Human

Human CDC34 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11443-ACR from Sino Biological Species Human

Human CDC34 ORF clone(NM_004359.1) - CDCL183460 from Creative biogene Species Human

Human CDC34 ORF Clone (BC009850) - CDCS411747 from Creative biogene Species Human Accession P49427

Human CDC34 cDNA Clone(NM_004359.1) - CDFH003217 from Creative biogene Species Human

Search more