| Gene Symbol | Pdgfb |
|---|---|
| Entrez Gene | 24628 |
| Alt Symbol | SIS, c-sis |
| Species | Rat |
| Gene Type | protein-coding |
| Description | platelet-derived growth factor beta polypeptide |
| Other Description | PDGF subunit B|PDGF-2|Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis)|pdgf protein|platelet derived growth factor, B polypeptide|platelet-derived growth factor B chain|platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)|platelet-derived growth factor subunit B |
| Swissprots | Q05028 |
| Accessions | AAA65020 EDM15770 Q05028 BQ782530 CB580369 CB783426 L40991 AAA70048 Z14117 CAA78487 NM_031524 NP_113712 |
| Function | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted {ECO:0000250}. Note=Released by platelets upon wounding. {ECO:0000250}. |
| Tissue Specificity | Expressed in a distinct subpopulation of smooth muscle cells in injured arteries. |
| Top Pathways | Rap1 signaling pathway, PI3K-Akt signaling pathway, MicroRNAs in cancer, Choline metabolism in cancer, Cytokine-cytokine receptor interaction |